Green chemistry in medicinal chemistry: A review on sustainable approaches to the synthesis of biologically active compounds
1 Graduate Student, Industrial Chemistry Department, University of Ilorin, Nigeria.
2 Assistant Lecturer, University of Abuja, Nigeria.
Review Article
World Journal of Advanced Research and Reviews, 2024, 24(02), 1371–1382
Publication history:
Received on 29 September 2024; revised on 09 November 2024; accepted on 11 November 2024
Abstract:
The pharmaceutical industry's commitment to sustainability is reshaping drug development, centering on green chemistry principles to minimize environmental impact without compromising drug efficacy. This review explores transformative green chemistry approaches, emphasizing atom economy, waste reduction, and renewable feedstocks in synthesizing biologically active compounds. Key advancements such as biocatalysis, flow chemistry, and safer solvent alternatives demonstrate a path to efficient, lower-impact drug synthesis. These sustainable strategies, while challenged by regulatory and industrial constraints, showcase significant potential to reduce the pharmaceutical carbon footprint and environmental toxicity. Through the integration of green methodologies, the industry can address pressing ecological challenges, improve public health, and foster a paradigm shift toward sustainable pharmaceutical production.
Keywords:
Sustainability; Drug discovery; Green chemistry; Waste reduction; Renewable feedstocks; Environmental impact
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Copyright © 2024 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0