G10S an immunoglobulin peptide against melanoma
Experimental Oncology Unit, Department of Microbiology, Immunology and Parasitology, Federal University of São Paulo, São Paulo, SP, Brazil.
Research Article
World Journal of Advanced Research and Reviews, 2022, 14(01), 385–390
Article DOI: 10.30574/wjarr.2022.14.1.0331
Publication history:
Received on 12 March 2022; revised on 18 April 2022; accepted on 20 April 2022
Abstract:
Peptides are the end product of transcript processing, for example allow the great viral adaptations and their transfection between species arising pandemic threats or diseases devoid of nucleic acid like prions. So, because of their high specificity, peptides can be used for different therapeutic goals. In this work we describe in vitro action of a peptide named G10S this sequence is part of a group previously selected by ExPASy Proteomics Tools Compute to find immunoglobulin molecules look like defensins of protective natural immunity which showed activity against tumors, which motivated us to investigate this activity against murine B16F10 melanoma. Thus, that criterion is capable to generate molecules against tumor, for interfering in cell adhesion, viability, migration and cycle. To conclude, the present work suggests a functional molecule against tumor.
Keywords:
Peptide; Antitumor activity; Cell cycle; B16F10 melanoma; Aggressive tumor cells; Cell migration
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Copyright © 2022 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0