Department of Pharmaceutics, St John’s College of Pharmaceutical Sciences, Yemmiganur, Kurnool, Andhrapradesh, India.
Research Article
World Journal of Advanced Research and Reviews, 2024, 22(02), 1601-1611
Article DOI: 10.30574/wjarr.2024.22.2.1549
DOI url: https://doi.org/10.30574/wjarr.2024.22.2.1549
Received on 09 April 2024; revised on 18 May 2024; accepted on 21 May 2024
Transdermal drug delivery system (TDDS) is a widely accepted mode of drug delivery method due to various advantages and one of the novel routes for systemic delivery of drugs through intact skin. Topical drug administration is a systemic and localized method of delivering drugs through skin and is considered an attractive alternative to oral and parenteral routes. The aim of present study was to formulate and evaluate Matrix type transdermal drug delivery system (TDDS) of Carbamazepine was prepared by the solvent evaporation technique. Several batches were prepared by using combination of HPMC E-15, Eudragit RL-100, and Ethyl Cellulose different ratios. Propylene glycol was used as plasticizer and DMSO was incorporated as a permeation enhancer. These Formulated transdermal patches were characterized for their physicochemical parameters like thickness, weight variation, folding endurance, percentage moisture uptake, Percentage moisture uptake and In vitro drug release studies were examined. Among the above all formulation F6 was chosen as a best Formulation, because this optimised formulation showed satisfactory drug content, physical characteristic for its thickness, weight uniformity, percentage moisture content, percentage moisture uptake, and maximum % of drug release i.e., 93.95 % in 12 hours. The optimized formulation (F6) showed maximum highest percentage of drug release.
Carbamazepine; TDDS Patch; Hydrophilic Polymers; Hydrophobic polymer; Plasticizers; Permeation enhancer
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Bariki Rajasekhar, B Harish Reddy, G Aiman Farheen, J Anjinappa, K Rama Krishna, P Srilatha and S Farida. Formulation and evaluation of transdermal patch of carbamazepine. World Journal of Advanced Research and Reviews, 2024, 22(2), 1601-1611. Article DOI: https://doi.org/10.30574/wjarr.2024.22.2.1549