Department of Pharmaceutics, Sree Siddaganga College of Pharmacy, Mahalakshmi Nagara, 80 ft road, Batawadi, Tumkur -572103, Karnataka, India.
Research Article
World Journal of Advanced Research and Reviews, 2023, 20(03), 850-862
Article DOI: 10.30574/wjarr.2023.20.3.2498
Received on 28 October 2023; revised on 07 December 2023; accepted on 10 December 2023
Nanotechnology mediated drug delivery has been reported to enhance the drug efficacy, bioavailability, reduced toxicity and improve patient compliance by targeting the cells and tissues to elicit the desired pharmacological action. The main aim of the study was to formulate Glibenclamide loaded nanosponges and to evaluate them. Glibenclamide loaded nanosponges were prepared by Emulsion solvent diffusion method using different polymers (Ethyl cellulose, β- cyclodextrin, Hydroxy Propyl β- cyclodextrin, Pluronic F68). The FTIR test is conducted as the preliminary test, by this test there was no interaction between the drug and polymers. Then nanosponges were evaluated for particle size, PDI, zeta potential, SEM, entrapment efficiency and invitro drug release. The particle size ranged from 640.7 to 876.2 nm, PDI ranged from 0.456 to 0.707, zeta potential from -17.3 to -34.3 mV and entrapment efficiency was ranged from76.21 to 98.23% The cumulative percentage release from all nanosponges varied from 80.35 to 97.56% after 12 hours depending upon the drug and polymers ratio and F5 formulation showed highest drug release i.e., 97.53%. The release kinetic studies showed that the release first order diffusion controlled and the n value (0.8769) from the Korsmeyer- Peppa’s model indicated the release mechanism was non-fickian type.
Glibenclamide; Nanosponges; FTIR; In vitro drug release
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Kishor H B, K Manjunath and Suresh V Kulkarni. Formulation and evaluation of Glibenclamide loaded Nanosponges. World Journal of Advanced Research and Reviews, 2023, 20(3), 850-862. Article DOI: https://doi.org/10.30574/wjarr.2023.20.3.2498