Formulation and evaluation of floating tablet of esomeprazole by using natural gums
1 Konkan Gyanpeeth Rahul Dharkar College of Pharmacy and Research Institute, Karjat, Maharashtra, India.
2 Department of Pharmaceutics, Konkan Gyanpeeth Rahul Dharkar College of Pharmacy and Research Institute, Karjat Maharashtra, India.
Research Article
World Journal of Advanced Research and Reviews, 2024, 22(02), 1895–1907
Article DOI: 10.30574/wjarr.2024.22.2.1643
Publication history:
Received on 18 April 2024; revised on 25 May 2024; accepted on 28 May 2024
Abstract:
Objective: The main objective of the study was to develop and evaluate the gastroretentive floating tablet of esomeprazole magnesium trihydride, which is intended to increase patient compliance, deliver the medication in a controlled manner with less drug administration frequency, and increase the bioavailability of esomeprazole magnesium trihydrate.
Methods: In the current investigation, sodium bicarbonate was used as a gas-generating agent to create effervescent Esomeprazole magnesium trihydate floating tablet formulations. Natural polymers like moringa gum, Azadirachta indica gum, sodium alginate, xanthan gum were used in the formulation of the tablets, which were made utilizing direct compression technology.
Results: All of the developed formulations showed good In vitro buoyancy. The tablets remained buoyant for 12 hours. The drug release profiles revealed that Moringa gum tablets had a more uniform and regulated release, releasing 96% of the drug. In comparison, neem gum tablets released 89% of the drug, xanthan gum tablets released 93%, and sodium alginate tablets released 96%.
Conclusion: Out of all the formulations developed, the F1 formulation had the highest In vitro dissolution results compared to the other batches, exhibiting the requisite sustained release time and acceptable floating qualities.
Keywords:
Natural gum; Gastric residence time; Effervescent method; Buoyancy; Floating properties
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