Formulation and evaluation of fast dissolving films of repaglinide solid dispersio
Department of Pharmaceutics, Sree Siddaganga College of Pharmacy, B H Road, Tumakuru, Karnataka-572102, India.
Research Article
World Journal of Advanced Research and Reviews, 2020, 06(03), 262-274
Article DOI: 10.30574/wjarr.2020.6.3.0214
Publication history:
Received on 19 June 2020; revised on 26 June 2020; accepted on 27 June 2020
Abstract:
The aim of the research work is to formulate fast dissolving films of repaglinide solid dispersion. The major problem of repaglinide is its low solubility. To enhance the solubility of the drug repaglinide, it is made into Solid dispersion by Solvent evaporation method by using polyethylene glycol 4000 as carrier. Prepared repaglinide solid dispersion is formulated into fast dissolving films by solvent casting method by using various hydrophilic polymers like hydroxy propyl methyl cellulose E-15, polyvinyl pyrrolidone K-30 and polyvinyl alcohol in different concentration and glycerol as plasticizer. The compatibility of the drug with the excipients was confirmed by Fourier transform infrared spectroscopy studies. Various evaluation parameters were done for all the formulated films. They are Physical appearance, Surface texture, Thickness uniformity, Folding endurance, Drug-Excipient interaction studies, Disintegration study, Drug content uniformity, In-vitro release study, Permeation study, Stability study. The optimized formulation F3 has shown satisfactory disintegration time of 40 seconds and in-vitro drug release of 98.72 % within 8 minutes.
Keywords:
Repaglinide; Solid dispersion; Solvent evaporation method; Fast dissolving films; Solvent casting method
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