Finding a biomarker to predict patent ductus arteriosus in preterm babies

Maryam Veysizadeh 1, Mastaneh Khodadadi 1, Mohammad Reza Zarkesh 2, 3, *, Kamyar Kamrani 1, Mahbod Kaveh 1 and Mamak Shariat 4

1 Department of Pediatrics, Bahrami Hospital, Tehran University of Medical Sciences, Tehran, Iran.
2 Maternal, Fetal, and Neonatal Research Center, Family Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
3 Department of Neonatology, Yas Women Hospital, Tehran University of Medical Sciences, Tehran, Iran.
4 Breastfeeding Research Center, Family Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
 
Research Article
World Journal of Advanced Research and Reviews, 2022, 16(01), 259–265
Article DOI: 10.30574/wjarr.2022.16.1.1031
 
Publication history: 
Received on 07 September 2022; revised on 10 October 2022; accepted on 13 October 2022
 
Abstract: 
Background: Few studies have evaluated the relationship between the presence of PDA and cardiac troponin T (cTnT) levels; however, the results are conflicting. The present study aimed to compare blood cTnT levels among preterm neonates with and without PDA.
Methods: A case-control study was conducted at Iranian Hospital in 2021. For all included neonates, echocardiography examination was performed on admission time. According to the clinical presentation and echocardiography findings, preterm neonates were divided into the case (with PDA) and control (without PDA) groups. A blood test was also performed for all participants to detect levels of plasma cTnT. Finally, the levels of plasma cTnI (ng/ml) were compared between the case and control groups.
Results: Totally 36 neonates (12 with PDA and 24without PDA) aged 1.972±0.696 days entered the study. The mean neonatal Troponin T level was 116.352±83.470 ng/ml. The results have shown no significant difference between the groups regarding the means of Troponin level (124.506±113.138 and 112.275±66.546; P=0.476). The results have indicated that there were significant and inverse correlations between the cTnT level with the 1st (Correlation Coefficient= -0.450; P=0.006) and 5th (Correlation Coefficient=-0.532; P=0.001) minutes Apgar Scores. This relationship was also observed between the mean of TnT level and maternal gravidity (Correlation Coefficient= -0.356; P=0.033).
Conclusion: The results of the present study delineate no correlation between the presence of PDA and increased blood cTnT levels in preterm neonates. While low Apgar scores at 1 and 5 minutes as well as maternal gravidity could significantly change the levels of cardiac troponin T levels.
 
Keywords: 
Troponin T; Ductus Arteriosus; Patent; Premature Birth; Newborn
 
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