Fatal outcome in a high-grade myxofibrosarcoma: A case report

High-grade myxofibrosarcoma is an uncommon and aggressive soft tissue sarcoma, most frequently occurring in elderly patients and typically arising in the limbs. It demonstrates infiltrative growth, a myxoid stroma, and a high potential for metastasis. We present the case of a 74-year-old woman with a rapidly enlarging, ulcerated tumor on her left lower leg. Histopathological and immunohistochemical studies confirmed high-grade myxofibrosarcoma. Despite planned staging and therapeutic management, the patient died one month after diagnosis. This case underscores the aggressive nature of high-grade myxofibrosarcoma, even when superficially located, and highlights the importance of early detection and intervention.