Exploring the potential therapeutic value of Solanum lycopersicum L. phytoconstituents for Parkinson's disease through molecular docking analysis
1 National Raw Drug Repository, Central Ayurveda Research Institute, Uttar Pradesh-284002; Jhansi, CARI, CCRAS, Ministry of Ayush, Government of India.
2 Department of Pharmacy, Vishveshwarya Group of Institution GB Nagar Ghaziabad Bulandshahr GT Road Phase II Dadri Greater Noida Uttar Pradesh-203207, India.
3 GVM College of Pharmacy, Murthal Road, Sonipat, Haryana, India.
4 Department of Quality Assurance, Dayanand College of Pharmacy, Barshi Road, Latur, Maharashtra, India
5 Department of Pharmaceutical sciences, Siddhartha Group of institutions, Dehradun, Uttarakhand, India.
6 IIMT College of Medical Sciences, IIMT University, 'O' Pocket, Ganga Nagar - 250001, Meerut, Uttar Pradesh, India.
7 Department of Pharmacy, Central Ayurveda Research Institute, Uttar Pradesh-284002; Jhansi, CARI, CCRAS, Ministry of Ayush, Government of India.
Research Article
World Journal of Advanced Research and Reviews, 2023, 20(02), 488–501
Article DOI: 10.30574/wjarr.2023.20.2.2279
Publication history:
Received on 01 October 2023; revised on 06 November 2023; accepted on 08 November 2023
Abstract:
Parkinson's disease is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the brain, leading to motor and non-motor symptoms. The search for novel therapeutic agents to mitigate the progression of the disease and alleviate its symptoms has led to the exploration of natural compounds. Solanum lycopersicum L., commonly known as tomato, contains various phytoconstituents that have shown promise in neuroprotection and anti-inflammatory properties. This study aims to investigate the potential therapeutic value of Solanum lycopersicum L. phytoconstituents for Parkinson's disease through a comprehensive molecular docking analysis. Using state-of-the-art computational techniques, we will evaluate the binding interactions between these phytoconstituents and key protein targets associated with Parkinson's disease. The findings from this research may contribute to the development of new therapeutic strategies and drug candidates for the management of Parkinson's disease.
Keywords:
Solanum lycopersicum L.; Parkinson's disease; Carbidopa; Molecular docking; Phytoconstituents
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