Evaluation of valoneic acid and the cytostasis properties of lagerstroemia speciosa ethanolic leaf extract on the accumulation of MPS in the complete blood count of the albino rats

Karthik Mani and Sujatha Perumal Sivakumar *

Research Department of Zoology, Government Arts College (Autonomous), Coimbatore - 641 018, Tamil Nadu, India.
World Journal of Advanced Research and Reviews, 2024, 22(03), 629–637
Article DOI: 10.30574/wjarr.2024.22.3.1708
Publication history: 
Received on 01 May 2024; revised on 08 June 2024; accepted on 10 June 2024
Microplastics, also referred to as "microbeads," are a versatile kind of plastic that have numerous uses. The most widely used herbicide is glyphosate, which is regarded as non-toxic. However, excessive usage of it on agricultural land has contaminated the rivers and soils. These days, food, water, and soil all contain glyphosate residues. Glyphosate, a harmful substance, is quickly eliminated from humans and can be found in blood and urine, especially in exposed workers. It has severe acute and long-term toxicological consequences as a result. Medicinal plants, rich in bioactive phytochemicals, are crucial for preventing and treating diseases due to their curative efficacy. Lagerstroemia speciosa, a plant belonging to the Lythraceae family, is referred to as the "Pride of India". A combination derived from L. speciosa that includes one or more chemicals chosen from the gallo-tannins, ellagitannins, and valoneic acid dilactones group The Lythraceae family also includes the slightly acidic compound valoneic acid dilactone. The proposed study includes an evaluation of the valoneic acid and cytostasis effects of L. speciosa ethanolic leaf extract against MPs-glyphosate-induced albino rats blood profiles. The experimental design includes thirty rats who were randomly divided into five groups of six animals dosing up to 28 days: The first was the control group, which only used normal saline.  In the II group, Glyphosate received p.o for 28 days, the group III receives Glyphosate with valoneic acid for 28 days, the   IV and V groups are recovery groups, receives low and high concentration of LELE received 200mg/kg/day, p.o for 28 days.  The samples of blood are used to evaluate Hematological parameters like RBC, WBC, and platelets.
Microplastics; Lagerstroemia speciosa; Valoneic acid; Glyphosate; Red blood cells and Albino rats.
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