EVALUATION OF SEDATIVE ACTIVITY OF POTHOS SCANDENS LEAVES USING ZEBRAFISH (DANIO RERIO) MODEL

This experiment was performed to evaluate the main potential of sedative activity of money plant on zebrafish model(danio rerio), mainly known as pothos scandens leaves. scandens leaves are the best alternative to improve the usage of traditional medicines because, sedative drugs have been showing their side effects significantly on zebrafish model. And mainly traditional medicines have therapeutic properties. In this experiment leaves are extracted hot, cold and ethanolic and subjected to the animal model. This experiment is done in different intervals with various doses and concentrations. It shows some parameters like bending movements, tail flicking, slowing down of the zebrafish was observed after the treatment with the leaves extracts indicating the reduction of activity. The change in the behaviour of animal model enables us to understand the cns depressing activity when compared with the control and standard values. Due to presence of bioactive compounds, higher doses and ethanolic extracts produced better results. This study provide findings as scientific support for traditional use of these leaves in the safer and efficient use of sedative drugs