Evaluation of indicators of coagulation hemostasis and endothelial dysfunction in covid-19 convalescents
Department of Cardiology SI "Republican Specialized Scientific and Practical Medical Center of Therapy and Medical Rehabilitation", Tashkent, Uzbekistan.
Research Article
World Journal of Advanced Research and Reviews, 2023, 18(02), 116–120
Article DOI: 10.30574/wjarr.2023.18.2.0801
Publication history:
Received on 21 March 2023; revised on 02 May 2023; accepted on 04 May 2023
Abstract:
Purpose: Evaluation of indicators of coagulation hemostasis and humoral markers of endothelial dysfunction in COVID-19 convalescents.
Material and methods: 105 COVID-19 convalescents were examined. Patients were included in the study after suffering COVID-19 after 4-6 months. The average age of the surveyed was 51.8±6.7 years. Women made up - 64 (60.95%), men - 41 (39.05%). Hemostasis indicators were assessed by coagulogram parameters - fibrinogen level, determination of D-dimer by enzyme immunoassay, humoral factors of endothelial dysfunction - endothelin-1, von Willebrand factor, thrombomodulin by enzyme immunoassay.
Results: In the group of patients with elevated fibrinogen levels (more than 400 mg/dl), these values were significantly higher in terms of humoral markers of endothelial dysfunction than in patients with normal fibrinogen levels. Similarly, in patients with elevated levels of D-dimer, these values were significantly higher than in patients with normal levels of this indicator. When studying the levels of fibrinogen and D-dimer in the blood of COVID-19 convalescents, a direct correlation between them was established in relation to endothelin-1, VWF and thrombomodulin. There was a strong correlation between D-dimer and humoral factors endothelin-1 (r=0.88) and VWF (r=0.61), while thrombomodulin had a moderate correlation (r=0.56).
Conclusions: In the blood of COVID-19 convalescents, there was a significant increase in the level of fibrinogen and D-dimer. In COVID-19 convalescents, an increase in the level of markers of endothelial dysfunction was associated with indicators of the clinical course and indicators of fibrinogen and D-dimer.
Keywords:
COVID-19 convalescents; Hemostasis indicators; Markers of endothelial dysfunction; Highly sensitive C-reactive protein
Full text article in PDF:
Copyright information:
Copyright © 2023 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0