Evaluation of hepatic fibrosis in patients with chronic hepatitis B virus by non-invasive methods: Aspartate-to-platelet ratio index, Fibrosis-4, fibrotest and fibroscan

Laté Mawuli Lawson-Ananissoh 1, *, Aklesso Bagny 1, Oumboma Bouglouga 2, Laconi Kaaga 1, Gad Namdiro 1, Rafiou El-Hadji Yakoubou 2, Lidawu Roland-Moise Kogoe 1 and Debehoma Venceslas Redah 1

1 Hepato-Gastroenterology unit, Campus Teaching Hospital, Lome-Togo.
2 Hepato-Gastroenterology unit, Kara Teaching Hospital, Kara-Togo.
 
Research Article
World Journal of Advanced Research and Reviews, 2022, 13(01), 172–179
Article DOI: 10.30574/wjarr.2022.13.1.0767
 
Publication history: 
Received on 30 November 2021; revised on 04 January 2022; accepted on 06 January 2022
 
Abstract: 
Background: The process of hepatic fibrosis is common to the various etiologies of chronic liver disease such as viral hepatitis B.
Objective: To evaluate hepatic fibrosis by non-invasive markers such as Aspartate-to-Platelet Ratio Index (APRI), fibrosis-4 (FIB-4), fibrotest and fibroscan.
Patients and Method: This was a descriptive study during a period of 32 months. Included in our study were the records of outpatients, chronic carriers of hepatitis B virus without viral co-infection C, D or HIV, followed in the Gastroenterology unit of the Campus Teaching Hospital of Lome-Togo.
Results: We retained 222 patients. Among the patients, 148 patients (66.67%) were classified in Phase 3 (inactive carrying). Only 10 patients (4.50%) had a APRI score indicating a fibrosis stage ≥ F4 (presence of cirrhosis). A FIB-4 score indicating the presence of cirrhosis was found in 12 patients (5.40%). The most represented stage at fibrotest was the F0 stage (45.45%). Cirrhosis was noted in 6.06% of cases at fibroscan. Patients with APRI score ≤ 2 (96.23%) had a FIB-4 score ≤ 3.25, (p = 0.0088).
Conclusion: The evaluation of hepatic fibrosis during chronic hepatopathies is essential for patients care because it influences therapeutic decisions.
 
Keywords: 
Hepatic fibrosis; APRI; FIB-4; Fibrotest; Fibroscan; Togo
 
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Copyright information: 
Copyright © 2022 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0

 

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