Evaluation of hematological changes in Plasmodium falciparum–infected patients before and after artesunate-mefloquine treatment in Dak Lak province, Vietnam
1 Institute of Malariology, Parasitology and Entomology Quy Nhon, Binh Dinh, Vietnam.
2 Oxford University Clinical Research Unit (OUCRU), Vietnam.
Research Article
World Journal of Advanced Research and Reviews, 2020, 07(03), 235-240
Article DOI: 10.30574/wjarr.2020.7.3.0325
Publication history:
Received on 25 August 2020; revised on 24 September 2020; accepted on 26 September 2020
Abstract:
The hematological changes following treatment have been poorly understood. This study was designed to determine the hematological alterations and recovery in plasmodium falciparum – infected patients, treated with Artesunate/Mefloquin. A retrospective study was conducted in Dak Lak province, located in Central highlands Vietnam, between August 2019 and April 2020. All data from 80 patients who were diagnosed with P. falciparum infection – including clinical characteristics, and hematological parameters in 42 days follow up – were reviewed and analyzed. The results showed that there were no anemia (p<0.001), no leukopenia (p<0.001), no leukocytosis (p<0.001), but thrombocytopenia (p=0.018) in 80 patients before treatment. There was a slightly decrease in hemoglobin (HGB) at day 7 (p=0.05), then HGB significantly increased at day 42 after treatment (p<0.001). White blood cell (WBC) and platelet (PLT) counts rapidly recovered at day 7 after treatment (p<0.001 and p<0.001, respectively). This study indicated that malaria patients treated with Artesunate/Mefloquin exhibit important changes in hematological parameters with HGB and PLT counts being the two most important changes before and after treatment. This data could be useful for detection, treatment and prevention of malaria in Vietnam.
Keywords:
Malaria; Plasmodium falciparum; Treatment; Hematological recovery
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Copyright © 2020 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0