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eISSN: 2582-8185 || CODEN: WJARAI || Impact Factor 8.2 ||  CrossRef DOI

Research and review articles are invited for publication in March 2026 (Volume 29, Issue 3) Submit manuscript

Evaluation of the biomechanical and structural properties of bone allografts treated with a new cleaning process

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  • Evaluation of the biomechanical and structural properties of bone allografts treated with a new cleaning process

Guillaume Villatte 1, 2, *, Roger Erivan 1, 2, Regis Cueff 1, Yohann Wittrant 3, Stéphane Boisgard 1, 2 and Stéphane Descamps 1, 2

1 University of Clermont Auvergne, CNRS, SIGMA Clermont, ICCF, F-63000 Clermont-Ferrand, France.
2 Orthopedics and Traumatology Department. CHU Montpied Clermont-Ferrand, 63000 Clermont-Ferrand, France.
3 INRA, University of Clermont Auvergne, UMR 1019 Human Nutrition, CRNH Auvergne, 63000, Clermont-Ferrand, France.
 
Research Article
World Journal of Advanced Research and Reviews, 2022, 14(03), 608–616
Article DOI: 10.30574/wjarr.2022.14.3.0614
DOI url: https://doi.org/10.30574/wjarr.2022.14.3.0614
 
Received on 20 May 2022; revised on 23 June 2022; accepted on 25 June 2022
 
The use of allograft bone is becoming increasingly common. The intrinsic mechanical and structural properties of the graft are of major importance for osseointegration. Current cleaning treatments using chemical or physical products increase biosafety but may disturb these bone characteristics. A new cleaning treatment for cancellous and cortical bone by simple mechanical washing (sonication and centrifugation) and supercritical carbon dioxide (scCO2) treatment was developed. The mechanical and structural properties of allografts cleaned with this treatment were compared with those obtained after preservation by freezing at −80°C. Three-point bending, compression and hardness tests were performed for biomechanical analysis. The structural characteristics of the allografts were evaluated by microscanner (histomorphometry) and scanning electron microscopy (surface analysis). All the data showed that the cleaned bone was generally stiffer owing to delipidation but its structure remained similar to that of the frozen bone. Bone cleaned by this new treatment thus displayed mechanical and structural properties close to those of frozen bone.
 
Bone allograft; Cleaning process; Supercritical carbon dioxide; Mechanical analysis.
 
https://wjarr.com/sites/default/files/fulltext_pdf/WJARR-2022-0614.pdf

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Guillaume Villatte, Roger Erivan, Regis Cueff, Yohann Wittrant, Stéphane Boisgard and Stéphane Descamps. Evaluation of the biomechanical and structural properties of bone allografts treated with a new cleaning process. World Journal of Advanced Research and Reviews, 2022, 14(3), 608-616. Article DOI: https://doi.org/10.30574/wjarr.2022.14.3.0614

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