Evaluation of acute and subacute toxicity of the extract of allium cepa peels in Wistar rats
1 Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Bingham University, Karu, Nasarawa State, Nigeria.
2 Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Jos, Plateau State, Nigeria.
3 Department of Pharmacology and Toxicology, Faculty of Pharmacy, Federal University, Oye-Ekiti, Ekiti State, Nigeria.
Research Article
World Journal of Advanced Research and Reviews, 2023, 18(02), 1173-11880
Article DOI: 10.30574/wjarr.2023.18.2.0839
Publication history:
Received on 29 March 2023; revised on 24 May 2023; accepted on 26 May 2023
Abstract:
Allium cepa is a popular recipe used traditionally to treat diabetes, cardiovascular diseases, cancer, wounds and infections. The acute and sub-acute oral toxicity profile of the aqueous extract of Allium cepa peels were evaluated in wistar albino rats in order to determine its safety for use in traditional medicine. The median lethal dose (LD 50) body weights and food intake were determined. The acute oral toxicity of the peel extract was carried out in accordance with OECD guideline 423. In addition to this, the haematological parameters and biochemical parameters were also evaluated. The median lethal dose (LD 50) of the extract was greater than 2000 mg/kg when given orally in the rats. There were no significant changes in the level of haematological parameters and biochemical parameters. The results from this study indicates that Allium cepa peels are relatively safe, hence supporting its use in traditional medicine.
Keywords:
Allium cepa peels; Acute toxicity; Subacute toxicity; Haematological parameters; Biochemical parameters
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Copyright © 2023 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0