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eISSN: 2581-9615 || CODEN: WJARAI || Impact Factor 8.2 ||  CrossRef DOI

Research and review articles are invited for publication in April 2026 (Volume 30, Issue 1) Submit manuscript

From endothelial dysfunction to advanced cardiovascular disease: A case report of cardiometabolic progression

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  • From endothelial dysfunction to advanced cardiovascular disease: A case report of cardiometabolic progression

Michael Mario Vélez Lora 1, *, Joaquín Alberto Chois Antequera 1, Mauro Alonso Moreno Artuz 1 and María Mónica González Chinchilla 2

1 Internal Medicine Resident, Universidad Libre. Barranquilla, Colombia.

2 Physician, Universidad Metropolitana. Barranquilla, Colombia.

Case Report

World Journal of Advanced Research and Reviews, 2026, 29(03), 1054-1057

Article DOI: 10.30574/wjarr.2026.29.3.0615

DOI url: https://doi.org/10.30574/wjarr.2026.29.3.0615

Received on 04 February 2026; revised on 08 March 2026; accepted on 11 March 2026

Background: Endothelial dysfunction represents one of the earliest pathophysiological events in the development of atherosclerotic cardiovascular disease. Metabolic abnormalities such as dyslipidemia, prediabetes, and overweight contribute to oxidative stress, vascular inflammation, and progressive impairment of nitric oxide bioavailability.

Case presentation: A 60-year-old male with cardiometabolic risk factors presented with progressive dyspnea and was diagnosed with severe dilated cardiomyopathy and multivessel coronary artery disease.

Conclusion: This case highlights the continuum from endothelial dysfunction to advanced cardiovascular disease.

Cardiovascular risk; Endothelium; Atherosclerosis; High blood pressure; Prediabetes; Dyslipidemia; Inflammation

https://wjarr.com/sites/default/files/fulltext_pdf/WJARR-2026-0615.pdf

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Michael Mario Vélez Lora, Joaquín Alberto Chois Antequera, Mauro Alonso Moreno Artuz and María Mónica González Chinchilla. From endothelial dysfunction to advanced cardiovascular disease: A case report of cardiometabolic progression. World Journal of Advanced Research and Reviews, 2026, 29(03), 1054-1057. Article DOI: https://doi.org/10.30574/wjarr.2026.29.3.0615.

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