Emerging computational and pharmacological study of topiramate: A brief review
1 Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, Hamdard Nagar, New Delhi – 110062, India.
2 Department of Computer Engineering, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
3 Department of Cardiology, Fortis Heart Institute, New Delhi -110025, India.
Review Article
World Journal of Advanced Research and Reviews, 2024, 21(01), 624–633
Publication history:
Received on 25 November 2023; revised on 02 January 2024; accepted on 05 January 2024
Abstract:
Topiramate, a second-generation antiepileptic drug used to manage and treat epileptic seizures was approved by the FDA in 1996 as a solo or supplementary for the therapy of epilepsy. The frequency, severity, quality of life, and adverse events that topiramate has on epilepsy patients, including children and adolescents, are summarized in this review. The medication has a generally favorable safety profile and is well accepted, although monitoring the patient's medication, preventing its abuse, and improving patient outcomes all require knowledge. Despite the numerous scientific theories that surround the drug, more research into the uniqueness of medicine is required. This review will highlight the drug profile, synthesis, pharmacology, ADME properties, and computational study of topiramate.
Keywords:
Topiramate; Anticonvulsants; Synthesis; Molecular docking; Spectral information; HPLC.
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Copyright © 2024 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0