Electrospinning-modified Pt/CeO2 nano bandage as a promising therapy to reduce secondary brain injury

Alfiani Zukhruful Fitri Rifa’i; Rizqi Apsari Fairuz Kamila; Clara Alverina; Reny I’tishom

doi:10.30574/wjarr.2022.13.1.0771

eISSN: 2581-9615 || CODEN: WJARAI || Impact Factor 8.2 || CrossRef DOI

Research and review articles are invited for publication in March 2026 (Volume 29, Issue 3) Submit manuscript

Electrospinning-modified Pt/CeO2 nano bandage as a promising therapy to reduce secondary brain injury

Alfiani Zukhruful Fitri Rifa’i ¹, Rizqi Apsari Fairuz Kamila ^{1, } and Clara Alverina ¹, Reny I’tishom ^{2, }

¹Medical Program, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.

² Department of Biomedical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.

Review Article

World Journal of Advanced Research and Reviews, 2022, 13(01), 298-304

Article DOI: 10.30574/wjarr.2022.13.1.0771

DOI url: https://doi.org/10.30574/wjarr.2022.13.1.0771

Publication history

Received on 30 November 2021; revised on 09 January 2022; accepted on 11 January 2022

Abstract

Traumatic brain injury (TBI) continues to be a major contributor to morbidity, disability, and mortality in all age groups. Initial brain damage is accompanied by acute and irreversible primary damage to the parenchyma, while subsequent secondary brain damage often progresses slowly over months to years, thus providing a window for therapeutic intervention. The most frequent case which happened is excessive oxidative stress and calcium release after brain injury. Although some traditional antioxidants have been clinically approved, the efficacy is far from satisfactory due to their low ROS-scavenging efficiency, instability, toxicity, or inadequate penetration of the blood-brain barrier. Moreover, the combination of Nanozyme based-bandage with Pt/CeO2 atom catalysis with electrospinning nanofibers N-type voltage-gated calcium channel blocker (SNX-185) is predicted to be as promising as a potential novel to reduce secondary injury of TBI. Therefore, the duo could cut down morbidity and mortality rates because of TBI in the future, noninvasively.

Keywords

Traumatic brain injury; Secondary Injury; Nanozymes; SNX-185; Electrospinning nanofiber

Download Article PDF

https://wjarr.com/sites/default/files/fulltext_pdf/WJARR-2021-0771.pdf

Preview Article PDF

How to cite this article

Alfiani Zukhruful Fitri Rifa’i, Rizqi Apsari Fairuz Kamila, Clara Alverina and Reny I’tishom. Electrospinning-modified Pt/CeO2 nano bandage as a promising therapy to reduce secondary brain injury. World Journal of Advanced Research and Reviews, 2022, 13(1), 298-304. Article DOI: https://doi.org/10.30574/wjarr.2022.13.1.0771

Copyright © Author(s). All rights reserved. This article is published under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0), which permits use, sharing, adaptation, distribution, and reproduction in any medium or format, as long as appropriate credit is given to the original author(s) and source, a link to the license is provided, and any changes made are indicated.

All statements, opinions, and data contained in this publication are solely those of the individual author(s) and contributor(s). The journal, editors, reviewers, and publisher disclaim any responsibility or liability for the content, including accuracy, completeness, or any consequences arising from its use.

Developed & Designed by VS Infosolution

Electrospinning-modified Pt/CeO2 nano bandage as a promising therapy to reduce secondary brain injury

Alfiani Zukhruful Fitri Rifa’i ¹, Rizqi Apsari Fairuz Kamila ^{1, } and Clara Alverina ¹, Reny I’tishom ^{2, }

Preview Article PDF

Get Certificates

Issue details

Electrospinning-modified Pt/CeO2 nano bandage as a promising therapy to reduce secondary brain injury

Alfiani Zukhruful Fitri Rifa’i 1, Rizqi Apsari Fairuz Kamila 1, * and Clara Alverina 1, Reny I’tishom 2, *

Preview Article PDF

Get Certificates

Issue details

Alfiani Zukhruful Fitri Rifa’i ¹, Rizqi Apsari Fairuz Kamila ^{1, } and Clara Alverina ¹, Reny I’tishom ^{2, }