The effect of propolis-xenograft on the expression of SOX2, SOX9, and woven bone in alveolar bone remodeling
Department of Prosthodontic, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Research Article
World Journal of Advanced Research and Reviews, 2022, 15(03), 298–305
Article DOI: 10.30574/wjarr.2022.15.3.0923
Publication history:
Received on 13 August 2022; revised on 18 September 2022; accepted on 20 September 2022
Abstract:
Objective: This study was intended to analyze the expression of SRT-box transcription factor (SOX)2, SOX9 and woven bone in the preservation of tooth extraction sockets due to induction with propolis extract and bone graft.
Materials and methods: 56 Cavia cobaya was divided into four groups according to the socket filling material used: control group, a propolis extract group, a bovine xenograft group, and a propolis extract-bovine xenograft group. An incisor tooth was extracted from each subject and the resulting socket filled with specific materials based on the group of which it was a member. After 3 days and 7 days, the Cavia cobaya were sacrificed in order to obtain their mandibles. Histopathological samples were made by means of hematoxylin-eosin and immunohistochemical staining under a light microscope at 400x magnification. Statistical analysis: The results were analyzed using one-way ANOVA.
Results: A combination of propolis extract and bovine xenograft produced the highest expressions of SOX2, SOX9, and woven bone on day 3 and day 7, followed by the propolis group. The combination group experienced a significant difference with the control group on day 3 and day 7 (p<0.001). Even though the combination group presented the highest expressions, the results of a Tukey HSD test indicated no significant difference between the propolis and combination groups on day 3 and day 7.
Conclusion: A combination of propolis and bovine xenograft increased the expressions of SOX2, SOX9, and woven bone. Further research is required to validate the bone remodeling acceleration hypothesis with regards to propolis.
Keywords:
SOX2; SOX9; Woven Bone; Propolis; Alveolar Bone Remodeling; Medicine
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