The effect of methanolic extract of Corchorus olitorius on some kidney and liver functional indices of Albino rats
1 Department of Plant Science and Biotechnology, Faculty of Natural Sciences, University of Jos, Nigeria.
2 Department of Obstetrics and Gynecology, Federal University Teaching Hospital Owerri, Nigeria.
3 Department of Medical Laboratory Sciences, Faculty of Health Sciences and Technology, University of Jos, Nigeria.
4 Department of Histopathology, Jos University Teaching Hospital, Jos, Nigeria.
Research Article
World Journal of Advanced Research and Reviews, 2023, 19(02), 367–379
Publication history:
Received on 22 June 2023; revised on 04 August 2023; accepted on 05 November 2023
Abstract:
The use of medicinal plants has over the years gained wide acceptance among the populace globally and Corchorus olitorius is inclusive. This study is aimed at evaluating the effect of methanolic extract of Corchorus olitorius on some Kidney and Liver functional indices of albino rats. Through the exhaustive maceration technique, 80 % methanolic extract of this plant was prepared and used throughout the study. The acute and subacute effects of the extract following oral administration in the animal were studied. The LD50 of the extract was estimated to be higher than 5000 mg/kg. Oral administration of 100, 1000, 1600, 2900 and 5000 mg/kg doses daily for 14 days did not produce any mortality among the rats. There was no significant difference at P>0.05 in weight before and after administration of the methanolic extract. However, there was a significant (P<0.05) and dose-dependent increase in the haematological, renal and liver biochemical parameters supported by histological evidence like mild periportal inflammation and mild congestion of the liver as well renal tubular necrosis by Corchorus olitorius at 5000 mg/kg body weight dose. From this study, Corchorus olitorius has a high degree of safety at a low concentration and the plant is relatively safe for consumption.
Keywords:
Corchorus olitorius; Median Lethal Dose (LD50); Acute; Subacute; Safety.
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