Effect of a medicated yavagu and lifestyle modification in prediabetes: A comparative clinical trial

Neelima S 1 *, Sunitha V K 2 and Sajitha Bhadran 1

1 Department of Swasthavritta, Government Ayurveda College, Thiruvananthapuram, Kerala, India.
2 Department of Swasthavritta, Government Ayurveda College, Kannur, Kerala, India.
Review Article
World Journal of Advanced Research and Reviews, 2024, 22(03), 1014–1025
Article DOI: 10.30574/wjarr.2024.22.3.1805
Publication history: 
Received on 05 May 2024; revised on 15 June 2024; accepted on 17 June 2024
Prediabetes is a state of intermediate hyperglycaemia. It remains a high-risk state for developing diabetes mellitus which resembles the concept of Prameha in Ayurveda. Prediabetes may be correlated with Prameha purvarupa, and they arrive as an opportunity to act early. In Ayurveda, the goal of Prediabetic management is to normalise the blood sugar level by giving attention to three aspects - Aushadha (Medicine), Ahara (Diet) and Vyayama (Exercise). This study is to assess the effect of a Medicated yavagu and Lifestyle modification in Prediabetes. This Medicated yavagu is mentioned in the Kerala’s traditional therapeutic treatise Yogamrutam, Prameha chikitsa. It is prepared with Raktasali (Oryza sativa) and Mudga (Vigna radiata) in kashaya of 8 herbal ingredients-Paaranthi root (Ixora coccinea), Khadira sara (Acacia catechu), Bhadra root (Aerva lanata), Saalaparni root (Pseudarthria viscida), Dusparsa root (Tragia involucrata), Vasukah root (Spermacoce hispida), Daaruharidra stem (Coscinium fenestratum) and Ghotika root (Portulaca oleracea). A Pre-post Interventional study was done in 60 participants with 30 each randomly allocated to Intervention group (Group I) and Comparison group (Group II). In Group I, Medicated yavagu was administered along with Lifestyle modification which includes dietary restriction and exercise. In Group II, Lifestyle modification alone was advised. The study period was 30 days. FBS and PPBS levels were analyzed on 0th, 15th and 31st day. The study was analyzed statistically using paired t-test, student’s t-test and repeated measures ANOVA. After intervention, both Group I and II elicited statistically highly significant reduction in FBS and PPBS values (p<0.001). When comparing both groups, the effect was statistically highly significant (p<0.001) in reducing FBS and PPBS levels. The results indicates that Medicated yavagu along with Lifestyle modification is more effective than Lifestyle modification alone in Prediabetes.
Prediabetes; PramehaPrameha purvarupa; Medicated yavagu; Lifestyle modification
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