Effect of duration of diabetic in glutamic acid decarboxylase autoantibodies and HbA1c in children with T1DM
Department of Biology, College of Science, University of Kerbala, 56001, Kerbala, Iraq.
Research Article
World Journal of Advanced Research and Reviews, 2023, 18(02), 870–876
Article DOI: 10.30574/wjarr.2023.18.2.0909
Publication history:
Received on 08 April 2023; revised on 15 May 2023; accepted on 18 May 2023
Abstract:
Background: a metabolic condition characterized by a failure in the metabolism of proteins, lipids, and carbohydrates that is brought on by problems with insulin production. When multiple autoantibodies, such as those against glutamic acid decarboxylase, are present against different insulin antigens, type 1 diabetes is present.
Objective: To estimate the Glutamic Acid Decarboxylase Autoantibodies and assessment of HbA1c in type 1 DM.
Methods: 40 children with diabetes participated, while 10 kids in the control group had blood sugar levels that were normal. HbA1c levels for each participant are measured as part of a quantitative ELISA test for the identification of circulating autoantibodies against glutamic acid decarboxylase in human serum.
Results: All the pathological samples showed an increase in the concentration of Anti-GAD compared to the control. Samples of patients with diabetes for 5 years or more showed a decrease in Anti-GAD concentration compared to patients with diabetes for less than five years, but the decrease was not significant
Conclusion: There was positive association between duration of type 1 Diabetes Mellitus and Glutamic Acid Decarboxylase Autoantibodies
Keywords:
Anti-GAD; T1DM; HbA1C; Autoantibodies
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