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eISSN: 2581-9615 || CODEN: WJARAI || Impact Factor 8.2 ||  CrossRef DOI

Research and review articles are invited for publication in March 2026 (Volume 29, Issue 3) Submit manuscript

Effect of Alpha Lipoic Acid (ALA) Supplementation in Goat Oocyte In Vitro Maturation Media on Superoxide Dismutase (SOD) and 8-Hydroxy-2'-Deoxyguanosine (8-OHdG) Levels

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  • Effect of Alpha Lipoic Acid (ALA) Supplementation in Goat Oocyte In Vitro Maturation Media on Superoxide Dismutase (SOD) and 8-Hydroxy-2'-Deoxyguanosine (8-OHdG) Levels

Akhmad Afifudin Al-Anshori 1, Epy Muhammad Luqman 2 and Widjiati Widjiati 2, *

1 Magister of Reproductive Biology, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia.
2 Department of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia.
 
Research Article
World Journal of Advanced Research and Reviews, 2023, 20(02), 397-403
Article DOI: 10.30574/wjarr.2023.20.2.2292
DOI url: https://doi.org/10.30574/wjarr.2023.20.2.2292
 
Received on 23 September 2023; revised on 06 November 2023; accepted on 08 November 2023\
 
Introduction: This study explains about the effect of Alpha Lipoic Acid (ALA) supplementation in goat oocyte In Vitro maturation media on Superoxide Dismutase (SOD) levels and 8-Hydroxy-2'-Deoxyguanosine (8-OHdG) levels with the aim of determining the status of balanced intracellular redox status and good oocyte quality.
Objective: This laboratory experimental study contained three treatment groups: no ALA (P0), 25 μmol/L ALA supplementation (P1), and 50 μmol/L ALA supplementation (P2). SOD and 8-OHdG levels were measured using the ELISA method. SOD levels in group P0 were 1.41±0.40 pg/mL, group P1 were 2.04±0.50 pg/mL, and group P2 were 3.65±1.20 pg/mL. Data on 8-OHdG levels in the P0 group was 51.17±27.58 pg/mL, the P1 group was 11.21±5.98 pg/mL, and the P2 group was 12.66±6.01 pg/mL.
Results: The P1 group could not significantly increase the SOD level of the P0 group (p>0.05), while the P2 group could significantly increase the SOD level of the P0 group (p<0.05). Data on 8-OHdG levels in the P1 and P2 groups decreased significantly when compared to the P0 group (p<0.05).
Conclusion: ALA supplementation at a dose of 50 µmol/L in goat oocyte In Vitro maturation media can increase SOD levels and reduce 8-OHdG levels. 
 
Oocyte; Alpha Lipoic Acid; In Vitro Maturation; SOD; 8-OHdG
 
https://wjarr.com/sites/default/files/fulltext_pdf/WJARR-2023-2292.pdf

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Akhmad Afifudin Al-Anshori, Epy Muhammad Luqman and Widjiati Widjiati. Effect of Alpha Lipoic Acid (ALA) Supplementation in Goat Oocyte In Vitro Maturation Media on Superoxide Dismutase (SOD) and 8-Hydroxy-2'-Deoxyguanosine (8-OHdG) Levels. World Journal of Advanced Research and Reviews, 2023, 20(2), 397-403. Article DOI: https://doi.org/10.30574/wjarr.2023.20.2.2292

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