1 Department of Medical Laboratory Services, General Hospital Oghara, Delta State, Nigeria.
2 Department of Hematology and Blood Transfusion Science, Federal Medical Center Yola, Adamawa State, Nigeria.
3 Department of Medical Laboratory Science, University of Benin, Edo State, Nigeria.
4 Department of Medical Laboratory Science, Rivers State University, River’s state, Nigeria.
Research Article
World Journal of Advanced Research and Reviews, 2021, 11(02), 058-063
Article DOI: 10.30574/wjarr.2021.11.2.0365
Received on 26 June 2021; revised on 02 August 2021; accepted on 05 August 2021
Background/Objectives: Aged people with obesity are vulnerable to coagulation disorders arising from alterations in procaogulants. Therefore, this study aims to evaluate the effect of age on procaogulant such as: fibrinogen (FG), von willebrand factor (vWF), Soluble Vascular Cell Adhesion Molecules (sVCAM) tissue factor (TF), Tissue Plasminogen Activator (tPA) and Plasminogen Activator Inhibitor (PAI) in obese people.
Materials and Method: 312 subjects with age between 18 and 65years were enrolled for this study comprising of 111males and 201females who were further grouped into age ranges of 20-39years, 40-49years and 50-59years respectively. 4.5mls of venous blood was collected into Ethylene Diamine Tetra-acetic Acid (EDTA) container. Plasma obtained was analyzed using ELISA method.
Results: FG values in obese people within age range 20-29years was 100.59±209.23ng/ml while FG level of people within age range 40-49years and 50-59years were71.14±64.24ng/ml and 41.83±15.63ng/ml respectively at p<0.05. PAI of those within age range of 20-39years was 411.65±349.88pg/ml while PAI of people in age range of 50-59years was 265.92±64.30pg/ml. sVCAM of people in the age range of 20-39years was 8.24±12.61u/l and people within the age range of 50-59years had sVCAM value of 4.42±1.17u/l. TF values of people within the age range of 20-39years was 82.03±54.21pg/ml while people in the age range of 50-59years had TF value of 74.54±20.05pg/ml at P<0.05. vWF of people within age range of 50-59years was 84.88±58.96u/l while younger people in the age range of 20-29years had vWF value of 74.59±55.32u/l at P<0.05.
Conclusion: Procaogulants such as: FG, PAI, sVCAM and TF were higher in younger people than in older people with obesity at Sapele southern Nigeria.
Age; Obesity; Procoagulant; Sapele
Preview Article PDF
Kingsley Chukwuka Amaihunwa, Emmanuel Asuquo Etim, Everista Odaburhine Osime and Zacchaeus Awortu Jeremiah. Effect of age on procoagulants in people with obesity at Sapele, Southern Nigeria. World Journal of Advanced Research and Reviews, 2021, 11(2), 058-063. Article DOI: https://doi.org/10.30574/wjarr.2021.11.2.0365