Drug discovery, explain how lead compound delivers to the target site and claim if there are recommended antiviral drugs to COVID-19.

Elhadary Aya *

Industrial Biotechnology Department, Faculty of Science, Tanta University, Tanta, Egypt.
Review Article
World Journal of Advanced Research and Reviews, 2020, 07(01), 079-091
Article DOI: 10.30574/wjarr.2020.7.1.0241
Publication history: 
Received on 28 June 2020; revised on 07 July 2020; accepted on 08 July 2020
Drug design is a long and costly process taking many stages; start with target identification passing through target validation, lead identification, and candidate optimization of pre-clinical and clinical trials. Drug design types depend on screening of a large number of molecules to distinguish and can select the most effective drug with high pharmaceutical effect. Ligand and Structure Based Drug Design are the two types of drug design. The drug takes journey when administered into the body through several ways (oral, inhalation, Intravenous (IV), Intramuscular (IM)) to deliver its target site. Twenty years ago, Computational strategies applied to understand particular target molecules with hits achieving lead target and that helps in lead Identification and Optimization stages of drug design and development. Screening, molecular modification and rational drug design are the three approaches to search for a modern drug. Bioinformatics plays a vital role in the discovery of drug as Bioinformatics includes both the programmed preparing of huge amounts of existing information and the creation of modern sorts of data resource. Both required in case the information is to be changed into data and utilized to assist in drug discovery. This work will discuss what is the meaning of drug design? What are the stages of drug design? What are the drug design types? Computer- Aided Drug Design (CAAD), Approaches in the search for a new drug, What is the journey of drug to deliver its target site? What are the methods of drug delivery? And will discuss the recommended antiviral therapy in the management of COVID-19.
Drug design; CAAD; Antiviral drugs; COVID-19; Lopinavir-Ritonavir; Drug delivery.
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