1 Radiotherapy Department of Dalal Jamm Hospital, Cheikh Anta Diop University of Dakar, Senegal.
2 Gynecology Department of the Regional Hospital of Thiès, Iba Der Thiam University of Thies, Senegal.
3 Joliot Curie Institute of Dakar, Cheikh Anta Diop University of Dakar, Senegal.
Research Article
World Journal of Advanced Research and Reviews, 2023, 20(01), 024–031
Received on 17 September 2023; revised on 29 October 2023; accepted on 31 October 2023
Objective: Describe the epidemiological, diagnostic and therapeutic profile of breast cancer in Senegal.
Patients and Methods: One hundred and sixty patients with histological confirmation of breast cancer, treated consecutively between June 2018 and December 2020, were retrospectively included. Predefined clinical data were extracted from medical records containing patient demographic information, medical history, diagnostic features, and different treatment types. Data were collected, entered and analyzed using SPSS version 23.0 software.
Results: The median age of the participants was 48 years with extremes of 27 and 81 years. The average consultation time was 4 (± 2.6) months. Breast cancer was mainly discovered to clinical signs (91.3%). Screening mammography revealed only 5% of cases. The vast majority of patients had a tumor larger than 3 cm (78.2%). Molecular characterization by immunohistochemistry was studied in 87 patients (54.3%) with a predominance of the triple negative profile (36.8%). Neoadjuvant chemotherapy was performed in 111 patients (74%). One hundred and thirty-five patients (92.5%) had undergone a mastectomy with modified Patey type dissection and only 11 patients (7.5%) had conservative treatment. The histological complete response rate after neoadjuvant chemotherapy was 17.1%. The median time between surgery and radiotherapy was 6 months. All patients in the series received radiotherapy. It was adjuvant in 142 patients and exclusive for palliative purposes in 18 patients. It was moderately hypofractionated in 105 patients (65.6%); classic in 52 patients (32.5%). Acute toxicities of radiotherapy were mainly represented by grade 1 radiodermatitis (22.5%).
Conclusion: The descriptive analysis of these results shows the young age of the patients, the late diagnosis of breast cancer in our context and a treatment which is essentially based on neo-adjuvant chemotherapy and radical mastectomy.
Breast cancer; Diagnostic; Treatment; Radiotherapy; Senegal.
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Mouhamadou Bachir Ba, Rachidou Hamadou, Papa Alioune Diagne, Fatimatou Néné Sarr, Pape Massamba Diéné, Kanta Ka, Lamine Gueye, Doudou Diouf and Papa Macoumba Gaye. Diagnostic and therapeutic profile of patients treated for breast cancer in a radiotherapy unit: case of Dalal Jamm Hospital, Senegal. World Journal of Advanced Research and Reviews, 2023, 20(2), 024-031. Article DOI: https://doi.org/10.30574/wjarr.2023.20.2.2221