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eISSN: 2581-9615 || CODEN: WJARAI || Impact Factor 8.2 ||  CrossRef DOI

Research and review articles are invited for publication in April 2026 (Volume 30, Issue 1) Submit manuscript

Development and validation for the simultaneous estimation of olmesartan medoxomil and hydrochlorothiazide by using RP-HPLC methods

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  • Development and validation for the simultaneous estimation of olmesartan medoxomil and hydrochlorothiazide by using RP-HPLC methods

Anumalagundam Srikanth 1, *, Govindarao Yedlapalli 2, G Srikanth 3, Gummalla Lakshmi Harathi 4 and Singh Sarika Anil 1

1 Department of Pharmaceutical Analysis, Vasavi institute of pharmaceutical sciences, Vasavi Nagar, Peddapalli (Village), Sidhout (Mandal), YSR Kadapa (Dist), Andhra Pradesh-516247, India.
2 Department of Pharmaceutical Analysis and Quality Assurance, Siddahartha Institute of Pharmaceutical Sciences, Jonnalagadda Village, Narasaraopeta Mandal, Guntur District, Andhra Pradesh-522601, India.
3 Department of Pharmaceutics, Vasavi institute of pharmaceutical sciences, Vasavi Nagar, Peddapalli (Village), Sidhout (Mandal), YSR Kadapa (Dist), Andhra Pradesh-516247, India.
4 Ratnam Institute of Pharmacy, Pidathapolur Village, Muthukur Mandal, SPSR Nellore District,Andhra Pradesh-524 346, India.
 
Research Article
World Journal of Advanced Research and Reviews, 2023, 17(02), 686-696
Article DOI: 10.30574/wjarr.2023.17.2.0247
DOI url: https://doi.org/10.30574/wjarr.2023.17.2.0247
 
Received on 30 December 2022; revised on 10 Februay 2023; accepted on 13 February 2023
 
A simple, Accurate, precise method was developed for the simultaneous estimation of the Olmesartan Medoxomil and Hydrochlorothiazide in Tablet dosage form. Chromatogram was run through Inertsil -ODS C18,250 x 4.6 mm, 5m. Mobile phase containing Methanoland Bufferin the ratio of 80:20 was pumped through column at a flow rate of 10ml/min. Optimized wavelength for Olmesartan Medoxomil and Hydrochlorothiazidewas 260nm. Retention time of Olmesartan Medoxomiland Hydrochlorothiazide were found to be 3.270min and 4.566 min. %assay was obtained as 99.91% and 99.95% for Olmesartan Medoxomiland Hydrochlorothiazide respectively. Regression equation of Olmesartan Medoxomilis y = 30712x - 31891, and y = 16499x + 8683. Of Hydrochlorothiazide.
 
Olmesartan Medoxomil; Hydrochlorothiazide; RP-HPLC; Validation; Simultaneous Estimation. 
 
https://wjarr.com/sites/default/files/fulltext_pdf/WJARR-2023-0247.pdf

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Anumalagundam Srikanth, Govindarao Yedlapalli, G Srikanth, Gummalla Lakshmi Harathi and Singh Sarika Anil. Development and validation for the simultaneous estimation of olmesartan medoxomil and hydrochlorothiazide by using RP-HPLC methods. World Journal of Advanced Research and Reviews, 2023, 17(2), 686-696. Article DOI: https://doi.org/10.30574/wjarr.2023.17.2.0247

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