1 Departments of haemato-oncology and pediatric endocrinology, CHU Hassan II of Fez.
2 Faculty of Medicine, Pharmacy and Dentistry, Sidi Mohammed Ben Abdallah University of Fez.
Case Study
World Journal of Advanced Research and Reviews, 2024, 22(01), 1882-1886
Received on 20 March 2024; revised on 28 April 2024; accepted on 30 April 2024
Adrenocortical carcinoma is a rare tumor, representing 0.2% of pediatric cancers. Diagnosis is made on a combination of clinical, biological, radiological, and anatomopathological arguments. Treatment involves tumor excision surgery, sometimes supplemented by chemotherapy for forms with a high risk of recurrence. Prognosis is often reserved, with a non-negligible death rate.
This report presents three cases of adrenocortical carcinoma treated at our institution between 2017 and 2023. The patients were three girls aged 5 years, 8 months, and 11 years, respectively. They were admitted for signs of hyperandrogenism and arterial hypertension. The tumor was left adrenal in all patients. The histological score was Severe Weiss 6 or 7. All patients underwent tumor resection, and they all benefited from this procedure. Despite chemotherapy in one patient, normalization of blood pressure figures postoperatively, two patients progressed to recurrence and subsequently died. The objective of this study is, through three observations, to describe the problem of the management of adrenocortical carcinoma (ACC) on the one hand, and to review the literature on the management and the prognosis of corticosteroid ACC in children.
Corticoadrenaloma; Adrenal; Cortisol; Virilization; Cushing
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V. KASHAMA, G. OVIEBO ANDO, S. BOURAMDANE, K. ELMKADDEM, H. HBIBI, S. ABBROURAZAK and S. BENMILOUD. Corticoadrenaloma: A case report from the pediatric haemato-oncology and pediatric endocrinology departments at the Hassan II University Hospital of Fez. World Journal of Advanced Research and Reviews, 2024, 22(1), 1882-1886. Article DOI: https://doi.org/10.30574/wjarr.2024.22.1.1336