1 Department of Orthodontics, Faculty of Dental Medicine, Universitas Airlangga, Jl. Prof. Dr. Moestopo No. 47 Surabaya, East Java, Indonesia 60132, Surabaya, Indonesia.
2Study Program of Immunology, Postgraduate School, Universitas Airlangga, Jl. Airlangga No.4-6, Surabaya, East Java, Indonesia 60132, Surabaya, Indonesia.
3 Department of Dental Public Health, Faculty of Dental Medicine, Universitas Airlangga, Jl. Prof. Dr. Moestopo No. 47 Surabaya, East Java, Indonesia 60132, Surabaya, Indonesia.
4 Department of Dentomaxillofacial Radiology, Faculty of Dental Medicine, Universitas Airlangga, Jl. Prof. Dr. Moestopo No. 47 Surabaya, East Java, Indonesia 60132, Surabaya, Indonesia.
5 Master Program in Immunology, Postgraduate School, Universitas Airlangga, Jl. Airlangga No.4-6, Surabaya, East Java, Indonesia 60132, Surabaya, Indonesia.
Review Article
World Journal of Advanced Research and Reviews, 2022, 16(03), 043-048
Received on 17 October 2022; revised on 29 November 2022; accepted on 01 December 2022
Background: Tooth extraction is surgical treatment with clinical manifestation is alveolar bone resorption of 11-63% which potentially fails dental implant treatment. Socket preservation is bone regeneration treatment to minimize bone morphological changes in post-extraction using bone graft. Anti-inflammatory biomaterial is needed to modulate inflammatory cascade in the lesion. Anthocyanin ternatin is a flavonoid derived from butterfly pea (Clitoria ternatea) as an anti-inflammatory and antioxidants agent. Hydroxyapatite/β-Tricalcium Phosphate coralline (HA/β-TCP coralline) is a combination of bioceramic material from calcium carbonate heating of Porites spp. coral which has potential to induce osteogenesis, osteoinduction, and osteoconduction. Combination of Anthocyanin ternatin and HA/β-TCP coralline applied to the defect area in dried powder form to induce hard tissue regeneration.
Purpose: To describe the potential of combination of Anthocyanin ternatin and HA/β-TCP coralline as a socket preservation biomaterial in dental implant.
Review: Combination of Anthocyanin ternatin and dried powder HA/β-TCP coraline is applied in dental socket. Anthocyanin ternatin suppresses ROS and iNOS then inhibit NF-kB signaling pathway. Downregulation of the pathway decreases TNF-α and IL-1β/6 expression so the expression of RANKL is inhibited. Lowering of ROS followed by upregulated Ca2+ level from HA/β-TCP coralline causes the increase in DKK1 and PTEN expression so Akt and Wnt expression is induced. Upregulation of the proteins induces the BMP2/TGF-β/Smad1/5/8 signaling pathway activation manifest in the increase of Runx2, OCN, and Osx then the preosteoblast differentiation to osteoblast is increased.
Conclusion: Combination of Anthocyanin ternatin and HA/β-TCP coralline is potential as socket preservation biomaterial in dental implant.
Athocyaninn ternatin; Dental Implant; HA/β-TCP coralline; Medicine; Dentistry.
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Alexander Patera Nugraha, Agung Sosiawan, Amelia Aisyiah Anwar, Rifqah Ananda Mappananrang, Alqomariyah Eka Purnamasari, Nastiti Faradilla Ramadhani and Satutya Wicaksono. Combination of anthocyanin ternatin and hydroxyapatite/β-tricalcium phosphate coralline as a socket preservation biomaterial in dental implant: A narrative review. World Journal of Advanced Research and Reviews, 2022, 16(3), 043-048. Article DOI: https://doi.org/10.30574/wjarr.2022.16.3.1285