Clear cell carcinoma in endometrial pathology: A rare case study

Introduction: Clear cell carcinoma of the endometrium is a rare, aggressive tumor that spreads rapidly and frequently outside the uterus. Multimodal management is the weapon of choice in the treatment of clear cell carcinomas of the endometrium, but treatment must be based on the molecular classification of the tumor.
Report of the case: We report the clinical observation of a 45-year-old female patient followed for clear cell carcinoma of the endometrium. She received palliative chemotherapy with paclitaxel and carboplatin. Clear cell carcinoma of the endometrium belongs to histological type II endometrial cancer. Clear cell carcinoma expresses very little POLEmut and MMRd, but mainly expresses p53abn and p53wt/NSMP. P53abn and p53wt/NSMP tumors have poor outcomes after treatment. It has a poor prognosis despite treatment. Conclusion: Clear cell carcinoma of the endometrium is a rare and aggressive tumor, hence the importance of early diagnosis for rapid and optimal treatment.