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eISSN: 2581-9615 || CODEN: WJARAI || Impact Factor 8.2 ||  CrossRef DOI

Research and review articles are invited for publication in March 2026 (Volume 29, Issue 3) Submit manuscript

Cetuximab-based management of metastatic cutaneous squamous cell carcinoma in a heart transplant recipient: A case report and literature review

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  • Cetuximab-based management of metastatic cutaneous squamous cell carcinoma in a heart transplant recipient: A case report and literature review

Serge Emmanuel Bambule 1, 2. *, Francia Holguin 3, Hubert Pheulpin 3, Pierre Zuech 3, Larisa Martanovschi 3, Gabriela Tossen 3 and Geraldine Salmeron 3

1 Medical Oncology department, Faculty of Medicine and Pharmacy of Casablanca, Morocco.

2 Internal Medicine department, Faculty of Medicine, University of Kinshasa, DRC.

3 Hematology and Medical Oncology department, Poissy Intercommunal Hospital Center, France.

Case Report

World Journal of Advanced Research and Reviews, 2025, 27(02), 812-817

Article DOI: 10.30574/wjarr.2025.27.2.2931

DOI url: https://doi.org/10.30574/wjarr.2025.27.2.2931

Received on 06 July 2025; revised on 09 August; accepted on 12 August 2025

Background: Solid organ transplant recipients face a higher risk of cutaneous squamous cell carcinoma (cSCC) due to long-term immunosuppression. Managing metastatic cSCC in these patients is challenging because immune checkpoint inhibitors (ICIs) may cause graft rejection.

Case Presentation: A 67-year-old male heart transplant recipient developed multiple cSCCs with lung metastases during his illness. After surgery and radiotherapy, disease progression prompted systemic therapy with carboplatin and cetuximab. The patient achieved a complete metabolic response after seven cycles, with no graft rejection or severe side effects. Cetuximab maintenance therapy sustained the response.

Conclusion: Cetuximab offers a safe and effective treatment for advanced cSCC in heart transplant recipients, avoiding the risks of ICIs. This case shows that Cetuximab can be a good alternative treatment.

Cutaneous squamous cell carcinoma; Heart transplantation; Immunosuppression; Cetuximab

https://wjarr.com/sites/default/files/fulltext_pdf/WJARR-2025-2931.pdf

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Serge Emmanuel Bambule, Francia Holguin, Hubert Pheulpin, Pierre Zuech, Larisa Martanovschi, Gabriela Tossen and Geraldine Salmeron. Cetuximab-based management of metastatic cutaneous squamous cell carcinoma in a heart transplant recipient: A case report and literature review. World Journal of Advanced Research and Reviews, 2025, 27(2), 812-817. Article DOI: https://doi.org/10.30574/wjarr.2025.27.2.2931

Copyright © Author(s). All rights reserved. This article is published under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0), which permits use, sharing, adaptation, distribution, and reproduction in any medium or format, as long as appropriate credit is given to the original author(s) and source, a link to the license is provided, and any changes made are indicated.

All statements, opinions, and data contained in this publication are solely those of the individual author(s) and contributor(s). The journal, editors, reviewers, and publisher disclaim any responsibility or liability for the content, including accuracy, completeness, or any consequences arising from its use.

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