The cardiovascular mononeuropathy in Hemodialysis Patients analysed by a combination with reactivity tests to noninvasively evaluate skin sympathetic nerve activity and skin microvascular function by (LDF)
1 Department of Emergency, Civil Service Hospital, Minbhawan, Kathmandu, Nepal 44600.
2 Kathmandu University, Dhulikhel, Kavre, Nepal 6250.
3 Buddha Minimal Access Intervention (MAI) Centre Pvt, Ltd , Budhabari, Kathmandu, Nepal.
4 Lugansk State Medical University, Luhansk Oblast, 93000 Luhansk, Ukraine.
Research Article
World Journal of Advanced Research and Reviews, 2023, 18(03), 1240–1248
Publication history:
Received on 13 May 2023; revised on 24 June 2023; accepted on 26 June 2023
Abstract:
Aim: Although several patients with kidney disease have simultaneous dysfunction of the parasympathetic and sympathetic nervous systems, orthostatic hypotension during a hemodialysis (HD) procedure impacts not only the form of treatment but overall comfort of life for patients with HD. Despite a number of methods that are not invasive and have already been used to assess autonomous functioning, a system for monitoring malfunction throughout filtration of blood therapy which has yet to be discovered.
Methods: Regarding the purpose of monitoring the autonomous function of stable 40 regular HD patients and 35 healthy controls, we examined the clinical application of the laser-Doppler blood flow meter (LDF). By detecting the periflux blood flow decreasing velocity (PDV) while combined with the Valsalva manoeuvre, the LDF device which was used for an autonomous test. We also looked at the relationship between PDV and traditional atherosclerosis testing.
Results: The baseline PDV (5.30 ± 2.93), comparative to subjects who were in excellent condition (9.65 ± 7.10), was substantially decreased in the HD populace. Furthermore, we discovered a substantial connection between PDV and established parameters like heart rate fluctuation and ankle-brachial blood pressure indexing.
Conclusion: Regarding assessing autonomous functioning in hemodialysis patients, evaluation of PDV by LDF is just as effective as the standard approach. The benefit from regular and recurring assessments of autonomous dysfunction is made possible by the device's ease.
Keywords:
Parasympathetic; Sympathetic; Hemodialysis; ABI; PWV; Autonomous neuropathy; Periflux blood flow; Laser-Doppler blood flowmeter; Orthostatic hypotension
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