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eISSN: 2582-8185 || CODEN: WJARAI || Impact Factor 8.2 ||  CrossRef DOI

Research and review articles are invited for publication in March 2026 (Volume 29, Issue 3) Submit manuscript

Beyond serology: Leveraging radiological and pathological tools in seronegative primary biliary cholangitis

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  • Beyond serology: Leveraging radiological and pathological tools in seronegative primary biliary cholangitis

Nathalie Marina Pérez Fontalvo 1, *, Lorena Rocío Orozco Álvarez 1, Abel Enrique Manjarres Guevara 2, Michael Mario Vélez Lora 1 and Iván Alfredo De Ávila Consuegra 1

1 Department of Internal Medicine, Faculty of Health Sciences, Universidad Libre, Barranquilla, Colombia.
2 Department of Medicine and Health Sciences, Universidad del Norte, Barranquilla, Colombia. 
 
Case Study
World Journal of Advanced Research and Reviews, 2024, 22(03), 1105–1108
Article DOI: 10.30574/wjarr.2024.22.3.1833
DOI url: https://doi.org/10.30574/wjarr.2024.22.3.1833
 
Received on 07 May 2024; revised on 16 June 2024; accepted on 18 June 2024
 
Primary biliary cholangitis is a chronic autoimmune inflammatory disease that affects the bile ducts, presenting a broad clinical spectrum characterized by cholestasis and the presence of antimitochondrial antibodies. This report describes the case of a young adult presenting with fever, musculoskeletal pain, and altered bowel habits, alongside markers of hepatocellular damage with a cholestatic pattern, but with negative antimitochondrial and antinuclear antibodies. A liver biopsy revealed findings consistent with cholangitis. This case underscores the importance of considering cholangitis in the differential diagnosis of patients with abnormal liver biochemistry tests showing a cholestatic pattern, even in the absence of specific immune serological markers.
 
Primary Biliary Cholangitis; Autoimmune liver disease; Cholestasis; Liver Biopsy; PET.
 
https://wjarr.com/sites/default/files/fulltext_pdf/WJARR-2024-1833.pdf

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Nathalie Marina Pérez Fontalvo, Lorena Rocío Orozco Álvarez, Abel Enrique Manjarres Guevara, Michael Mario Vélez Lora and Iván Alfredo De Ávila Consuegra. Beyond serology: Leveraging radiological and pathological tools in seronegative primary biliary cholangitis. World Journal of Advanced Research and Reviews, 2024, 22(3), 1105-1108. Article DOI: https://doi.org/10.30574/wjarr.2024.22.3.1833

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