Beyond serology: Leveraging radiological and pathological tools in seronegative primary biliary cholangitis

Nathalie Marina Pérez Fontalvo 1, *, Lorena Rocío Orozco Álvarez 1, Abel Enrique Manjarres Guevara 2, Michael Mario Vélez Lora 1 and Iván Alfredo De Ávila Consuegra 1

1 Department of Internal Medicine, Faculty of Health Sciences, Universidad Libre, Barranquilla, Colombia.
2 Department of Medicine and Health Sciences, Universidad del Norte, Barranquilla, Colombia. 
Case Study
World Journal of Advanced Research and Reviews, 2024, 22(03), 1105–1108
Article DOI: 10.30574/wjarr.2024.22.3.1833
Publication history: 
Received on 07 May 2024; revised on 16 June 2024; accepted on 18 June 2024
Primary biliary cholangitis is a chronic autoimmune inflammatory disease that affects the bile ducts, presenting a broad clinical spectrum characterized by cholestasis and the presence of antimitochondrial antibodies. This report describes the case of a young adult presenting with fever, musculoskeletal pain, and altered bowel habits, alongside markers of hepatocellular damage with a cholestatic pattern, but with negative antimitochondrial and antinuclear antibodies. A liver biopsy revealed findings consistent with cholangitis. This case underscores the importance of considering cholangitis in the differential diagnosis of patients with abnormal liver biochemistry tests showing a cholestatic pattern, even in the absence of specific immune serological markers.
Primary Biliary Cholangitis; Autoimmune liver disease; Cholestasis; Liver Biopsy; PET.
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