Autoimmune thyroid diseases and genetic factors
1 Department of Biochemistry, Azerbaijan Medical University, Baku, Azerbaijan.
2 Department of Medical and Biological Physics, Azerbaijan Medical University, Baku, Azerbaijan.
Review Article
World Journal of Advanced Research and Reviews, 2022, 16(01), 690–696
Article DOI: 10.30574/wjarr.2022.16.1.1038
Publication history:
Received on 09 September 2022; revised on 18 October 2022; accepted on 21 October 2022
Abstract:
The autoimmune thyroid condition with the highest prevalence is Hashimoto's thyroiditis (HT). Autoimmune thyroid diseases (AITD), including Graves’ disease (GD) and Hashimoto’s thyroiditis, arise due to complex interactions between environmental and genetic factors. Each is presenting with distinct clinical features. Significant progress has been made in our understanding of the mechanisms leading to AITD. Because of the complex nature of AITD, caused by their polygenic nature and a complex mode of inheritance, there are still more questions to be answered than answers that can be given, especially about the nature of Hashimoto’s thyroiditis. One of the cornerstones to understanding illness pathophysiology and creating better treatments is figuring out the genetic component of AITD. Common HT and GD genes have been identified, as well as genes that are characteristic of only one of those diseases.
Keywords:
Autoimmune thyroid diseases; Genetic factors; Graves’ disease; Hashimoto’s thyroiditis
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