Atypical posterior reversible encephalopathy syndrome presenting with cortical laminar necrosis: A case report

Posterior reversible encephalopathy syndrome (PRES) represents a neurological disorder with varied clinical presentation and typical imaging findings of predominant vasogenic edema in the parieto-occipital regions. The imaging abnormalities found in PRES are usually reversible. In some rare cases, it can lead to irreversible damage to the cerebral parenchyma, leading to cortical laminar necrosis, which is an atypical feature of PRES. We describe a unique case of a patient admitted for an atypical PRES presenting with generalized tonic-clonic seizures and imaging features of cortical laminar necrosis. To our knowledge, our case is only the third one reported of PRES carrying imaging features of cortical laminar necrosis.