Department of Oral Medicine, Faculty of Dental Medicine, Airlangga University, Surabaya, East Java, Indonesia.
Research Article
World Journal of Advanced Research and Reviews, 2024, 24(03), 854-860
Received on 02 November 2024; revised on 09 December 2024; accepted on 11 December 2024
Angular cheilitis (AC), an inflammatory condition affecting the corners of the mouth, is commonly observed in HIV-positive populations and has potential as a clinical marker of immune suppression. This scoping review systematically examined studies to assess the association between AC HIV-positive individuals, with a particular focus on CD4+ cell counts and viral loads. A literature search across PubMed, ScienceDirect, and Google Scholar identified relevant studies, emphasizing the clinical characteristics, prevalence, and immunological indicators associated with AC. Findings indicate that AC prevalence increases as CD4+ counts decline, suggesting its utility as an early marker of HIV progression. The data also reveal a high co-occurrence of AC with oral candidiasis, further supporting its association with advanced immunosuppression. Statistical analyses from reviewed studies demonstrated significant correlations between low CD4+ levels and increased risk of AC, reinforcing the potential of AC as a diagnostic cue for immune decline. This review highlights AC as a non-invasive and cost-effective marker that could support early diagnosis and intervention in resource-limited settings, thereby improving HIV management outcomes.
Angular Cheilitis; HIV; Immune Suppression; CD4+; Oral Candidiasis; Diagnostic Marker; HIV Progression
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Reiska Kumala Bakti, Yasmin Kamila Putri, Indah Alya Zahra and Dhea Rima Rohita Zulfa. The association of angular cheilitis and HIV patients. World Journal of Advanced Research and Reviews, 2024, 24(3), 854-860. Article DOI: https://doi.org/10.30574/wjarr.2024.24.3.3765