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eISSN: 2581-9615 || CODEN: WJARAI || Impact Factor 8.2 ||  CrossRef DOI

Research and review articles are invited for publication in April 2026 (Volume 30, Issue 1) Submit manuscript

Antiplasmodial activity of Anthocleista djalonensis leaves extracts against clinical isolates of Plasmodium falciparum and multidrug resistant K1 strains

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  • Antiplasmodial activity of Anthocleista djalonensis leaves extracts against clinical isolates of Plasmodium falciparum and multidrug resistant K1 strains

Brice Kouakou Bla 1, *, Oléfongo Dagnogo 1, Rolland Gueyraud Kipré 1, Opportune Gogo Ballé 1, Jonhson David Trébissou 1 and Joseph Allico Djaman 1, 2

1 UFR of Biosciences, University of Felix Houphouët Boigny, 22 BP 582, Abidjan 22.
2 Department of Clinical and Fundamental Biochemistry, Institute Pasteur of Cote d’Ivoire, 01 BP 490 Abidjan 01, Cote d’Ivoire.
 
Research Article
World Journal of Advanced Research and Reviews, 2020, 08(03), 130-138
Article DOI: 10.30574/wjarr.2020.8.3.0464
DOI url: https://doi.org/10.30574/wjarr.2020.8.3.0464
 
Received on 01 October 2020; revised on 09 December 2020; accepted on 11 December 2020
 
Information collected from nine (09) traditional healers in the Moronou village in the Department of Toumodi revealed that Anthocleista djanlonensis is regularly used by the population for primary health care in the processing of malaria. Evaluation of the In vitro antiplasmodial activity showed that the aqueous extracts inhibit growth of clinical isolates and chloroquinoresistant strains (K1) with IC50 of 8.29 µg/mL and 10.23 µg/mL while the ethanolic extracts had IC50 of 37.65 µg/mL and 46.07 µg/mL on the same strains respectively. Results of the In vitro antimalarial bioassay showed that aqueous extracts have promising antiplasmodial effects on clinical isolates and on Plasmodium falciparum multidrug resistant K1 strain (3 µg/mL <IC50 <15 µg/mL). Phytochemical screening revealed that the extracts contain mainly alkaloids, polyphenols, polyterpenes and flavonoids 
 
Medicinal plants; Toumodi, malaria; Phytochemical screening; Côte d’Ivoire; Anthocleista djalonensis
 
https://wjarr.com/sites/default/files/fulltext_pdf/WJARR-2020-0464.pdf

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Brice Kouakou Bla, Oléfongo Dagnogo, Rolland Gueyraud Kipré, Opportune Gogo Ballé, Jonhson David Trébissou and Joseph Allico Djaman. Antiplasmodial activity of Anthocleista djalonensis leaves extracts against clinical isolates of Plasmodium falciparum and multidrug resistant K1 strains. World Journal of Advanced Research and Reviews, 2020, 8(3), 130-138. Article DOI: https://doi.org/10.30574/wjarr.2020.8.3.0464

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