Antiplasmodial activity of Anthocleista djalonensis leaves extracts against clinical isolates of Plasmodium falciparum and multidrug resistant K1 strains
1 UFR of Biosciences, University of Felix Houphouët Boigny, 22 BP 582, Abidjan 22.
2 Department of Clinical and Fundamental Biochemistry, Institute Pasteur of Cote d’Ivoire, 01 BP 490 Abidjan 01, Cote d’Ivoire.
Research Article
World Journal of Advanced Research and Reviews, 2020, 08(03), 130-138
Article DOI: 10.30574/wjarr.2020.8.3.0464
Publication history:
Received on 01 October 2020; revised on 09 December 2020; accepted on 11 December 2020
Abstract:
Information collected from nine (09) traditional healers in the Moronou village in the Department of Toumodi revealed that Anthocleista djanlonensis is regularly used by the population for primary health care in the processing of malaria. Evaluation of the In vitro antiplasmodial activity showed that the aqueous extracts inhibit growth of clinical isolates and chloroquinoresistant strains (K1) with IC50 of 8.29 µg/mL and 10.23 µg/mL while the ethanolic extracts had IC50 of 37.65 µg/mL and 46.07 µg/mL on the same strains respectively. Results of the In vitro antimalarial bioassay showed that aqueous extracts have promising antiplasmodial effects on clinical isolates and on Plasmodium falciparum multidrug resistant K1 strain (3 µg/mL <IC50 <15 µg/mL). Phytochemical screening revealed that the extracts contain mainly alkaloids, polyphenols, polyterpenes and flavonoids
Keywords:
Medicinal plants; Toumodi, malaria; Phytochemical screening; Côte d’Ivoire; Anthocleista djalonensis
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