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eISSN: 2581-9615 || CODEN: WJARAI || Impact Factor 8.2 ||  CrossRef DOI

Research and review articles are invited for publication in April 2026 (Volume 30, Issue 1) Submit manuscript

Antidepressant and nootropic activity of aqueous extract of Bougainvillea glabra

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  • Antidepressant and nootropic activity of aqueous extract of Bougainvillea glabra

Parikshit V. Choudhari 1, *, Vanita G. Kanse 2, A. Venkatachalam 3 and Punam R. Pal 4

1 Faculty of Pharmacy, Pacific Academy of Higher Education and Research University, Udaipur, Rajsthan-313003.
2 Oriental College of Pharmacy, Sanpada, Navi Mumbai, Maharashtra-400705.
3 Pacific Academy of Higher Education and Research University, Udaipur, Rajsthan-313003.
4 Faculty of Pharmacy, Shri Jagdishprasad Jhabarmal Tibrewala University, Jhunjhunu, Churu Road, Vidyanagari, Churela, Rajasthan-333001.
 
Research Article
World Journal of Advanced Research and Reviews, 2021, 10(01), 334-339
Article DOI: 10.30574/wjarr.2021.10.1.0163
DOI url: https://doi.org/10.30574/wjarr.2021.10.1.0163

 

Received on 14 March 2021; revised on 23 April 2021; accepted on 26 April 2021
 
The aim of this analysis was to assess antidepressant & nootropic capacity of Bougainvillea Glabra aqueous extract (BGAE). Forced swim test, tail suspension test, & tetrabenazine mediated catalepsy & ptosis models were used to assess BGAE's antidepressant efficacy in mice at doses of 250 & 500 mg/kg orally. Morris water maze with elevated plus maze (EPM) was used to test nootropic behaviour. Normal medications for antidepressant & nootropic function were imipramine (25 mg/kg) & piracetam (300 mg/kg), respectively. Antioxidant assays such as DPPH & TBARS were used to validate antidepressant & nootropic function. When comparison to car, pre-treatment with BGAE resulted in substantial dose-dependent decrease in immobility time in both FST & TST. (P0.005) Tetrabenazine-induced catalepsy & ptosis were both decreased dramatically. Furthermore, in MWM & EPM, BGAE demonstrated dose-dependent cognitive enhancing behaviour. In DPPH assay, BGAE had IC50 of 17.39 g/ ml, & in TBARS assay, it had IC50 of 398.71 gm/ ml. BGAE has antidepressant & nootropic activities that are equivalent to imipramine & piracetam at doses of 250 & 500 mg/kg, respectively, which may be due to its effect on neurotransmitters & antioxidant function.
 
Depression; Nootropic activity; Bougainvillea Glabra; Antioxidant
 
https://wjarr.com/sites/default/files/fulltext_pdf/WJARR-2020-0163.pdf

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Parikshit V. Choudhari, Vanita G. Kanse, A. Venkatachalam and Punam R. Pal. Antidepressant and nootropic activity of aqueous extract of Bougainvillea glabra. World Journal of Advanced Research and Reviews, 2021, 10(1), 334-339. Article DOI: https://doi.org/10.30574/wjarr.2021.10.1.0163

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