1 Biomedical Laboratory of the China-Guinea Friendship Hospital, Kipé, Cité des Médecins, Commune Ratoma 30 BP: 710 Conakry, Republic of Guinea.
2 Faculty of Health Sciences and Techniques, Department of Medicine, Chair of Fundamental Sciences, Gamal Abdel Nasser University of Conakry, PO Box: 1147 Republic of Guinea.
3 Microbiology Laboratory, Department of Biology, Faculty of Sciences, Gamal Abdel Nasser University of Conakry BP: 1147 Republic of Guinea.
Research Article
World Journal of Advanced Research and Reviews, 2021, 09(01), 075-085
Article DOI: 10.30574/wjarr.2021.9.1.0492
Received on 21 December 2020; revised on 01 January 2021; accepted on 03 January 2021
Introduction: Escherichia coli (E. coli) is one of the main bacterial species associated with urinary tract infections. Nowadays, this bacterium is becoming more and more resistant to antibiotics. Objective: The aim of this study was to determine the antibiotic sensitivity profiles of all strains of E. coli isolated from urine during the period from September 1st, 2018 to March 13th, 2019 at the Biomedical Laboratory of the China-Guinea Friendship Hospital of Kipé in Conakry.
Materiel and Methods: Cultures were done on different agar media. Bacterial identification, antibiograms and determination of minimum inhibitory concentrations (MIC) were performed on the Vitek 2 Compact 15 automated system.
Results: A total of 66 strains of E. coli have been isolated from patients of both sexes. The sex ratio (M/F) was 0.43. The mean age of the patients was 50.83 years. The majority of strains were sensitive to imipenem (96.96%), amikacin (96.96%), ertapenem (94.73%), gentamicin (69.23%), tobramycin (60, 60%), cefoxitin (64.28%), cefotaxime (62.50%), piperacillin/tazobactam (77.4%), amoxicillin/clavulanic acid (50.00%) and nitrofurantoin (87%). In contrast, the majority of strains were resistant to ampicillin (81.81%), cefalotin (62.02%), ticarcillin (88.00%), nalidixic acid (82.75%), ciprofloxacin (56.06%), ofloxacin (56.00%) and combination of trimethoprim/sulfamethoxazole (83.60%), sometimes with high MICs.
Conclusion: Our results show that urinary tract infections due to E. coli are more frequently observed in females than in males. Some of these strains studied exhibited multidrug resistance profiles to antibiotics. Among the classes of antibiotics tested, carbapenemes, nitrofurans, aminoglycosides, appear to be more active on E. coli uropathogenes in Guinea.
Escherichia coli; Antibiotics; Sensitivity; UTI; Kipé/Conakry
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Abdoulaye Makanéra, Talibi Camara, Amadou Sadjo Diallo, Rabouan Mohamed Chamassi, Mariam Condé, Mamadou Alpha Diallo, Mariama Condé, Tiguidanké Diakité, Daouda Camara, Alpha Oumar Barry, Ousmane Sy and Demba Magassouba. Antibiotic sensitivity profile of uropathogenic Escherichia coli strains at the China-Guinea Friendship Hospital of Kipé in Conakry (Guinea). World Journal of Advanced Research and Reviews, 2021, 9(1), 075-085. Article DOI: https://doi.org/10.30574/wjarr.2021.9.1.0492