1 Medical Study Program, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia, 60131.
2 Department of Microbiology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia, 601313.
3 Department of Anatomy, Histology, and Pharmacology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia, 60131.
Research Article
World Journal of Advanced Research and Reviews, 2024, 21(03), 634-640
Article DOI: 10.30574/wjarr.2024.21.1.0051
Received on 27 November 2023; revised on 06 January 2024; accepted on 08 January 2024
Typhoid fever is a disease with extensive epidemiological distribution, causing high morbidity and mortality. The lack of effectiveness in prevention and treatment contributes to its continued mass occurrence. Salmonella Typhi bacteria are the main etiological cause of typhoid fever and have demonstrated resistance to various typhoidal antibiotics. This study aims to explore alternative possibilities for these issues, both curatively and preventively. Eucalyptus (Melaleuca leucadendra) is known to contain numerous antibacterial compounds, with 1.8 cineole as the main antibacterial compound. This compound exerts antibacterial effects by disrupting bacterial cell membranes and walls. Ecoenzyme are also recognized for their antibacterial effects, containing antibacterial compounds such as acetic acid, citric acid, lipase enzyme, trypsin enzyme, and amylase enzymes. This research is a laboratory experimental study conducted using the agar-well diffusion method on Mueller Hinton agar media, with the diameter of the inhibition zone as the test result. The findings indicate that all tested concentrations of eucalyptus ecoenzyme (10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, and 100%) show no inhibitory zone in all three test replications. This result suggests that eucalyptus (Melaleuca leucadendra) ecoenzyme produced by Lamongan’s MSMEs does not exhibit antibacterial effects on Salmonella Typhi.
Ecoenzyme; Eucalyptus (Melaleuca leucadendra); Salmonella typhi; Antibacterial; Typhoid fever
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Bilal Burhanuddin Baihaqi, Wiwin Retnowati, Danti Nur Indiastuti and Eko Budi Koendhori. Antibacterial effect of eucalyptus (Melaleuca leucadendra) ecoenzyme produced by Lamongan’s MSMEs against Salmonella Typhi. World Journal of Advanced Research and Reviews, 2024, 21(1), 634-640 . Article DOI: https://doi.org/10.30574/wjarr.2024.21.1.0051