Anti-ulcerogenic activity of the powder fraction of leaves of Aspillia africana against ethanol-induced gastric ulcer in rats: Possible role of mucus and antioxidant effect
1 Department of Life Science, Higher Teacher Training College Bertoua, University of Bertoua, Bertoua, Cameroon.
2 Multidisciplinary Research groups, Higher Teacher Training College, University of Bertoua, Bertoua, Cameroon
3 Department of Animal Biology and Physiology, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon.
4 Department of Neuroscience, University of Montreal, Montreal, Canada.
5 Department of Pharmacy, Pharmacology and Toxicology, School of Veterinary Medicine and Sciences, University of
Ngaoundere, Ngaoundere, Cameroon.
6 Department of Biological Sciences, Faculty of Science, University of Ngaoundere, Ngaoundere, Cameroon.
Research Article
World Journal of Advanced Research and Reviews, 2023, 20(02), 599–608
Publication history:
Received on 27 September 2023; revised on 08 November 2023; accepted on 11 November 2023
Abstract:
Massive alcohol drinking can lead to gastric ulcer. In the present study we investigated the gastroprotective effect of powder fraction of the leaves of Apillia africana (AA) in ethanol (EtOH) induced oxidative stress and peptic ulcer in rats. The rats were divided into six treatment groups, which were the normal control group, negative control group (ethanol-induced) and tree treatment groups: AA at the doses of 100 mg/kg body weight (BW), 200 mg/kg BW and 400 mg/kg BW, and the positive control group treated with famotidin at the dose of 100 mg/kg BW. Gastroprotective effect was measured by the ulcerative lesion index, ulcer surface area, percentage of lesion area. Antioxidant and histopathological analyses were also conducted to gain additional data regarding the gastroprotective effect of AA in the rats’ stomachs. AA showed protected the gastric mucosa from ethanol ulceration, as revealed by the improved macroscopic and histological appearance. AA significantly increased the gastric homogenate content of GSH and inhibited the lipid peroxidation as revealed by the reduced gastric content of malondialdehyde (MDA). AA possesses gastro-protective activity, which could be attributed to a mucus production, antioxidant, and regeneration activities.
Keywords:
Gastric ulcer; Aspillia africana; Powder fraction; Reactive oxygen species; Histothology
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