1 Normale High Scool /01 BP 1757 Ouagadougou 01/ Institute of Science and technology, Ouagadougou, Burkina Faso.
2 University Joseph KI-ZERBO /03 BP 7021 Ouagadougou 03/Departement of Animale Biology and Animal Physiology/ Physiology Animal Laboratory, Burkina Faso.
3 DORI University Center / University Thomas SANKARA/ 12BP 417 ouagadougou 12, Burkina Faso.
4 National Center for Scientific and Technological Research (CNRST)/ Department of Animale Production/ 04 BP 8645 Ouagadougou 04, Burkina Faso.
5 Nazi Boni University/ 01 BP 3770 Ouagadougou 01, Burkina Faso.
Research Article
World Journal of Advanced Research and Reviews, 2023, 20(02), 683-689
Article DOI: 10.30574/wjarr.2023.20.2.2295
Received on 01 October 2023; revised on 09 November 2023; accepted on 11 November 2023
Synthetic anthelmintic (AHs) have always been used in veterinary medicine. The increasing development of resistance to these AHs in livestock parasites threatens animal health and global production, calling into question their effectiveness. In vitro egg hatch inhibition assay (EHA) and larval development test (LDT) performed showed ovicidal and larvicidal activities of four AHs compared to the control (PBS). However, a suspicion of Haemonchus contortus resistance to Bolumisole M1 (IC50 = 0.122µg/mL) and Ivomec-D (IC50 = 0.130µg/mL) was recorded after the EHA. Similarly, resistance was observed to Bolumisole M1 (IC50 = 0.024µg/mL), Ivomec-D (IC50 = 0.07µg/mL) and Kelanthic (IC50 = 0.144µg / mL) following the LDT. These results show that cases of parasite resistance to AHs exist in small ruminants in Burkina Faso. Therefore, a reasoned use of AHs could be a good approach in the control of gastrointestinal nematodes of small ruminants in Burkina Faso. Subsequent in vivo studies should be conducted to confirm this resistance in the real conditions of these ruminants.
Haemonchus contortus; Synthetic chemicals anthelmintics; Small ruminants; Resistance
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Généviève ZABRE, Elisabeth OUEDRAOGO, Boureima TRAORE, Basile TINDANO, Adama KABORE, Balé BAYALA, Hamidou H. TAMBOURA and Adrien M.G. BELEM. Anti-parasitic activities of four synthetic chemicals anthelmintics on Haemonchus contortus. World Journal of Advanced Research and Reviews, 2023, 20(2), 683-689. Article DOI: https://doi.org/10.30574/wjarr.2023.20.2.2295