Anti-Alzheimer potential of coumarin derivatives: A review
1 Sanskar College of Pharmacy and Research (SCPR), Opp. Jindal Pipes ltd, NH-24, Jindal Nagar, Ghaziabad, Uttar Pradesh 201302, India.
2 Sunder Deep Pharmacy College (SDPC), NH-24, Delhi-Hapur Road, Dasna, Ghaziabad, Uttar Pradesh 201015, India.
3 Lingaya's Vidyapeeth, Nachauli, Jasana Road, Old Faridabad, Haryana, India.
Review Article
World Journal of Advanced Research and Reviews, 2023, 20(01), 825-835
Publication history:
Received on 03 September 2023; revised on 15 October 2023; accepted on 18 October 2023
Abstract:
Alzheimer’s is a type of neurodegenerative diseases (NDs) found in old age people which main causes the dementia and various brain disorders. FDA approved drugs used commonly in treatment of moderate to severe Alzheimer's disease are Donepezil, Rivastigmine, Galantamine and Memantine. However, these approved drugs provide only palliative support not complete cure. So, urgency of new molecules has been becoming so important to cure this complex Disease.
Coumarin or 2-H-Chromen-2-one is an oxygenated heterocyclic compound, which is isolated from plants named Dipteryx odorata Willd, (Fabaceae). Synthetic coumarin derivatives has been well presence in literature due to existence of their potential pharmacological activities in literature. This review covers the anti-Alzheimer activities of chemically synthesized coumarin derivatives from 2016-2023. Coumarin derivatives profound found exhibits potential anti-Alzheimer activities in literature. Coumarin derivatives showed their anti-Alzheimer potential through various pharmacological pathways such as monoamine oxidase (MAO) inhibitor, acetylcholinesterase (AChE) & Butyl cholinesterase (BuChE) inhibitory activity, Aβ amyloid inhibition, Beta secretase 1 (BACE1 inhibitors). Multi-target directed ligands (MTDLs) approach also extensively reported to design and synthesis of novel coumarin scaffold as potential multifunctional Anti-Alzheimer activities in last one decade. We also covered literature of some coumarin hybrids derivatives as potential Anti-Alzheimer activities. Some common synthetic methods of coumarin structure also covered in this review article. This review supported that coumarin derivatives found excellent anti-Alzheimer activities and it can be play major role to solve the problem of complex AD disease.
Keywords:
Coumarin derivatives; Acetylcholinesterase enzyme (AChE); Multi-target directed ligands (MTDLs); Perkin reaction; Cryptolepine
Full text article in PDF:
Copyright information:
Copyright © 2023 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0