1 Universidad Mayor, Sede Temuco, Chile.
2 Pain Study Laboratory, Faculty of Medicine, University of Chile, Santiago, 8380453, Chile.
3 Herman HenrÃquez Hospital, German Clinic, Temuco, Chile.
Research Article
World Journal of Advanced Research and Reviews, 2024, 23(02), 783–787
Received on 13 June 2024; revised on 03 August 2024; accepted on 06 August 2024
Several medicinal plants are used empirically as analgesics because their mechanism of action is not known. The study presented is related to the antinociceptive and anti-inflammatory properties of a crude extract of XL E MS that is used in different types of pain. The efficacy of the extract was compared with that of ibuprofen based on its ED50's of dose-response curves of each substance in the murine models of acetic acid writhing (WT), tail flick (TF), formalin hind paw (FHP), hot plate (HP) and Complete Freund´s adjuvant (CFA), tests. The data exhibit he following order of potency for ibuprofen: TF > CFA 1 DAY > CFA 7 DAYS > FHP II > FHP I > HP > WT. In the case of the XL E MS extract, the order of potency obtained was: CFA 7 DAYS > CFA 1 DAY > WT > FHP I > FHP II > HP > TF tests. The results demonstrate that XL E MS extract is less effective than ibuprofen in all the murine assay, with the exception of CFA 1 DAY, CFA 7 DAYS and WT. This difference could be due to the fact that the extract does not activate the same mechanisms or mediators of antinociception and anti-inflammation that ibuprofen triggers and the characteristics of the pain induced by each test. The results obtained suggest that although the effect of XL E MS extract is relatively moderate, it is useful as an analgesic-anti-inflammatory agent when used in traditional herbal medicine.
Ibuprofen; Herbal extract; Antinociception: Antiinflammation; Murine assays
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GABRIELA RUDOLPH M, HUGO F. MIRANDA and JORGE E RUDOLPH. Analgesia induced by ibuprofen and extract of XL E MS in preclinical murine assays. World Journal of Advanced Research and Reviews, 2024, 23(2), 783-787. Article DOI: https://doi.org/10.30574/wjarr.2024.23.2.2205