Ameliorating effect of soya bean (Glycine max) extract on the histology of the kidneys of sniper-induced rats

Objective: This research study was carried out to investigate the ameliorating effect of Soya bean (Glycine max) on the histology of kidneys of sniper-induced rats.

Methodology: Twenty-five rats weighing 110 g to 150 g were procured and acclimatized for two weeks, thereafter; they were divided into five groups of five rats each, and were housed in cages. The groups were designated as groups A - E. Group A served as the control group and was not induced, while groups B – E were induced. Group A and B received distilled water only, while groups C – E received Vitamin C, 200 mg/kg of body weight and 400 mg/kg of body weight of extracts of Soya bean respectively for 21 days orally through oro-gastric tube. On the 22^nd day, the animals were weighed, sacrificed via chloroform inhalation, and kidneys were harvested for histological study.

Results: Histopathological findings showed normal renal architecture with glomeruli (G), bowman space (BS), renal tubules (RT) and active tubular cell (TC) in group A, severe hemorrhagic glomeruli (HG) in group B, renal tissue with active glomeruli (G) and tubular cell (TC) in group C, mild regeneration  with  active tubular cells  and moderate  glomerular necrosis (GN) in group D, and renal tissue with active glomeruli (G)  and tubular cell (TC) in group E.

Conclusion: The extract of soya bean has ameliorating effect on the histology of kidneys of sniper-induced rats, and the ameliorating effect improves with increase in the dosages of the extract.