Allergic acute coronary syndrome: Amoxicillin/clavulanic acid intake

Filipa Ribeiro Lucas 1, *, João Gigante 2, Steve Harakeh 3 and Pedro Vieira 1

1 Internal Medicine, Unidade Local de Saúde de Castelo Branco (ULSCB), Castelo Branco, Portugal.
2 Clinical Pathology, Hospital Prof. Doutor Fernando da Fonseca, Amadora, Portugal.
3 King Fahd Medical Research Center, King Abdulaziz University, Saudi Arabia.
 
Case Study
World Journal of Advanced Research and Reviews, 2021, 11(02), 064–068
Article DOI: 10.30574/wjarr.2021.11.2.0369
 
Publication history: 
Received on 24 June 2021; revised on 02 August 2021; accepted on 04 August 2021
 
Abstract: 
Anaphylaxis rarely manifests as a vasospastic acute coronary syndrome (ACS). Kounis Syndrome (KS) is described as the coincidental occurrence of chest pain and clinical and laboratory findings of ACS. The prognosis depends on the magnitude of the initial allergic response, the patient’s sensitivity, comorbidities, the site of antibody antigen reaction, the allergen concentration, and the route of allergen entrance. We report a rare case of KS secondary to antibiotic allergy. This case may suggest that Kounis syndrome should be taught in the differential diagnosis of acute coronary syndromes. Clinicians should be aware of this adverse effect and consider it during diagnostic workup of myocardial injury.
 
Keywords: 
Allergic acute coronary syndrome; Kounis Syndrome; Amoxicillin-clavulanate; Chest pain; Adverse effect
 
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