Department of Pneumology, ARRAZI Hospital, Faculty of medicine and pharmacy, Caddy Ayyad university, Mohammed VI University hospital center, Marrakech, Morocco.
Case Study
World Journal of Advanced Research and Reviews, 2024, 23(03), 2014-2019
Received on 25 July 2024; revised on 14 September 2024; accepted on 16 September 2024
Dermatomyositis (DM) is a rare, heterogeneous autoimmune disease of unknown cause, characterised by non-infectious inflammatory involvement of the muscles and skin associated with vasculopathy. It is also associated with visceral manifestations, particularly of the lungs. Various respiratory manifestations, sometimes combined, may be observed in DM, including involvement of the aerodigestive tract, involvement of the respiratory muscles and diffuse interstitial pneumonitis (DIP). Diffuse interstitial lung disease (DIL) is common and can be acute in onset, and is often associated with a specific class of myositis autoantibodies, including anti-MDA-5 antibodies, which are associated with a particular phenotype of DM, in which muscle involvement is minimal or absent but the risk of rapidly progressive interstitial lung disease is particularly high. We report a case of rapidly progressive acute diffuse interstitial lung disease revealing amyopathic dermatomyositis characterised by the presence of anti-MDA-5 autoantibodies.
Dermatomyositis; MDA-5 antibody; Interstitial lung disease; Gottron papules.
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Maryem Hindi, Lina Romane, Hasna Yassine, Mohamed Ijim, Oussama Fikri and Lamyae Amro. Acute interstitial lung disease revealing dermatomyositis: Case study and analysis of diagnostic challenges. World Journal of Advanced Research and Reviews, 2024, 23(3), 2014-2019. Article DOI: https://doi.org/10.30574/wjarr.2024.23.3.2687