Synthesis and In-silico design of a novel silver metal ciprofloxacin compound
1 Department of Pharmaceutical sciences, Maharshi Dayanand University, Rohtak, Haryana, India.
2 Department of Pharmaceutical sciences, Kurukshetra University, Thanesar, Haryana, India.
3 Department of Pharmaceutical sciences, Lovely Professional University, Phagwara, Punjab, India.
4 Department of Pharmaceutical sciences, IIMT University, Meerut, Uttar Pradesh, India.
5 Department of Pharmaceutical sciences, Siddhartha Group of institutions, Dehradun, Uttarakhand, India
Research Article
World Journal of Advanced Research and Reviews, 2023, 18(01), 885–892
Article DOI: 10.30574/wjarr.2023.18.1.0707
Publication history:
Received on 10 March 2023; revised on 17 April 2023; accepted on 19 April 2023
Abstract:
Ciprofloxacin is a quinolone derivative with antibacterial properties. Quinolones, which share structural similarities with nalidixic acid, function as unidentate, bidentate, and bridging ligands during chelation. A key factor in increasing quinolones' biological activity is the presence of metal ions. Many transition metals, including Ni2+, Co2+, Ca2+, Zn2+, Ag2+, Au2+, Mn2+, Mg2+, and Fe2+, are often utilised as chelating agents. The ciprofloxacin silver ions was developed in the current study and then compared with two standard medications (ciprofloxacin and norfloxacin) and evaluated for in-silico investigations using (PDB ID: 2XCT). It was shown that the silver metal of the ciprofloxacin Analogue (L1) had a higher docking score and glide energy when compared to two standard medications like, norfloxacin and ciprofloxacin respectively. It has been demonstrated in in-silico studies that the synthesised novel silver metal of the ciprofloxacin analogue (L1) has significant potency against a wide range of bacterial and fungal diseases, making it an essential source for new antibacterial drugs that target bacterial and fungal diseases in the future.
Keywords:
Silver metal ion; Ciprofloxacin Analogue (L1); In-silico design; Schiff base; Docking result; Glide energy.
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