In-silico analysis of Lysenin as potential anti-cancer agents targeting sphingomyelin in colon cancer
1 Department of Biology, Faculty of Mathematic and Natural Sciences, Universitas Brawijaya, Indonesia.
2 Bachelor Program of Medicine, Faculty of Medicine, Universitas Brawijaya, Indonesia.
3 Bachelor Program of Biology, Faculty of Mathematics and Natural Sciences, Universitas Brawijaya, Indonesia.
4 Department of Anesthesiology, Faculty of Medicine, Universitas Brawijaya, Indonesia.
5 Department of Parasitology, Faculty of Medicine, Universitas Brawijaya, Indonesia.
6 Biomedical Central Laboratory, Faculty of Medicine, Universitas Brawijaya, Indonesia.
Research Article
World Journal of Advanced Research and Reviews, 2023, 18(01), 833–840
Publication history:
Received on 08 February 2023; revised on 13 April 2023; accepted on 15 April 2023
Abstract:
Colorectal cancer is a malignant neoplasm disease and is defined as a malignancy that occurs in the large intestine. In the world colon cancer ranks fourth meanwhile in Indonesia, colon cancer placed in the third rank after another cancer. The aim of this study is to find alternative way to help chemotherapy agent that already exist which is 5-FU for cure colon cancer. As already know 5-FU still lack of weakness so in this study hope that the sample that test in this study which is lysenin can be co-chemotherapy agent for colon cancer. Lysenin from coelomic fluid earth worm Lumbricus rubellus will bind with ligand sphingomyelin with docking method where the result will be new binding complex. After that the new complex will be test with hnRNP M4 membrane complex on colon cancer with docking method too and will see whether there’s binding affinity between lysenin sphingomyelin binding complexes with hnRNP M4.
Keywords:
Colon Cancer; Lysenin; Sphingomyelin; 5-FU; hnrnp M4
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Copyright © 2023 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0